Nasal Mucosal Hemodynamics in Nasal Allergy. Effect of Various Drugs.:-Effect of Various Drugs-

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Adrenaline, ipratropium or fenoterol was applied to one nasal cavity of patients with nasal allergy. The nasal mucosal blood volume (IHb) of both sides was measured with a tissue spectrum analyzer (TS-200, Sumitomo Electric Co. Ltd.) before and 5 min. after the application of the drugs.I) Unilateral application of adrenaline (0.01mg/ml, 0.12ml) decreased the IHb on the ipsilateral side but caused no change of the IHb on the contralateral side.II) Unilateral application of 20μg of ipratropium induced no change of IHb on either side.III) Unilateral application of 0.2mg or 0.4mg of fenoterol induced no change of IHb on either side.IV) Fenoterol (0.2mg) caused no significant difference in the IHb of patients with or without symptoms.V) In the patients treated with fenoterol (0.2mg), there was no significant difference of IHb between those who always used topical steroid and those who did not.These results suggest that the nasal mucosal capacitance vessels of patients with nasal allergy respond more to a-adrenergic stimulants than to β-adrenergic stimulants or anticholinergic agents.
耳鼻咽喉科臨床学会の論文