:Light Microscopic and Roentogenological Observations on the Effects of Ethane-1-hydroxy-1, 1-diphosphonate (EHDP) and Dichloromethylene diphosphonate (Cl2MDP) on Rat Tibia

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Young female rats (70-80g) were treated for 7 days with several doses of ethane-1-hydroxy-1, 1-diphosphonate (EHDP) or dichloromethylene diphosphonate (Cl2MDP).Effects of treatment on the changes in the thickness, growth, and mineralization of proximal epiphyseal plate and metaphysis of the tibia were assessed roentogenologically and histologically.Our results were as follows.1) With low doses (5-30mg/kg/day) of EHDP, resorption at the periosteal surface in the metaphysis was inhibited, so that the club-shaped appearance in the metaphysis was induced. It was similar to that seen in human osteopetrosis.2) With high doses (40-150mg/kg/day) of EHDP, the thickness of the epiphyseal plate was increased as three fold as control, and accumulation of osteoid tissue was observed.3) With every doses (5-70mg/kg/day) of Cl2MDP, the club-shaped appearance in the metaphysis occurred such as EHDP (low dose), but no change was found in the thickness of the epiphyseal plate.
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