Calcium antagonist diltiazem inhibits calcification enhanced by 2-thiophenecarboxylic acid in growth cartilage of rat in 1-hydroxyethylidene-1,1-bisphosphonate (HEBP)-induced rickets.

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2-Thiophenecarboxylic acid was shown to produce hypocalcemic and hypoglycemic effects in rats by Lloyd (1969). We reported previously that 2-TCA enhanced calcification in growth cartilage of rat in HEBP induced rickets. This action of 2-TCA was very similar to that of calcitonin. In this study, diltiazem, a calcium antagonist, suppressed the accelerated calcification due to 2-TCA in the growth cartilage. Eguchi had reported that diltiazem inhibited calcification promoted by calcitonin in the same experimental model. These results suggested that intracellular concentrations of calcium might play an important role in the occurrence of accelerated calcification due to 2-TCA and calcitonin in the HEBP induced rachitic rats.
西日本整形・災害外科学会の論文