A clinicopathologic study of 36 cases of malignant fibrous histiocytoma of soft tissues.

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A clinicopathologic study of 36 cases of malignant fibrous histiocytoma (MFH) of the soft tissues is reported. Of the 36 patients, 21 were males and 15 were females. The age of patients ranged from 37 to 93 years with the mean age of 63.4 years. The tumors occurred predominantly as a mass in proximal portions of the extremities (thigh: 11 cases, upper arm: 9 cases). Hand and foot were affected in none of the cases.Overall five-year survival is 44%. The prognosis of the patients was correlated with a few clinical and histologic features. The depth and the size of the tumor are correlated with the prognosis. The five-year survival rate, as estimated by Kaplan-Meier method, was 35% in the tumors involving the skeletal muscles, while 67% in the superficially located tumor. The patients with tumors, measured less than 5cm in the greatest diameter, carried a five-year survival of 68.6%, while 17.1% in patients with tumors measured more than 10cm in diameter. The patients with the tumors of myxoid type had better prognosis (63% five-year survival) than those with the tumor of pleomorphic subtype (35%). Other predominant histologic features, such as storiform pattern, herringbone pattern, low cellularity, dense collagenization, ect., seem to be good prognostic factors. In contrast, marked pleomorphism suggests poor prognosis.
西日本整形・災害外科学会の論文