The observation of bacterial adherence to biomaterials in vivo.

概要

論文の詳細を見る
Clinical reports clearly show that the presence of biomaterials makes adjacent tissues susceptible infection. The bacteria on biomaterial were examined by electron microscopy 10 days after intraperitoneal administration of stphylococci. This study shows that a large percentage of bacteria adhere to surfaces of biomaterials and form microcolonies surrounded by a biofilm. The bacterial glycocalyx seemed to mediate the formation of microcolonies. These microcolonies may adhere to inert or tissue surface by the interaction of their glycocalyx and their pili with surface components. These demonstration of bacterial adherence to biomaterials in vivo suggests that polysaccharide mucoid peribacterial films (glycocalyx) are among the initial and fundamental factors in infection and are significant factors in the resistance of these types of infections to host defense mechanisms and antibiotic therapy.
西日本整形・災害外科学会の論文