Clinical Observations of Vitamin D Resistant Rickets and Osteomalacia

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The results of the clinical observations of nine patients of Vitamin D resistant rickets and four patients of Vitamin D resistant osteomalacia were presented. The longest length of follow up of Vitamin D resistant rickets at Kyushu University was ten years. Treatment with a high dosage of Vitamin D was begun between 11/2 and 7 years of age. The dose of Vitamin D required for the treatment of rickets varied widely depending on the severity of the process and the age of the patient. The range necessary for adequate treatment varied 100, 000 to 400, 000 IU per day or more. Two patients showed hypercalcemia and other manifestations of Vitamin D intoxication. Three patients with deformity required osteotomy or other operation. In other patients deformities have improved with medical treatment alone.The clinical and radiological features of four patients of Vitamin D resistant osteomalacia first diagnosed in adult-hood were also described.Dwarfism and severe deformity of the legs were characteristic features. The loss of stature were resulted almost from shortness of the legs. Radiographic features were Looser zones, coarse trabecular pattern, increased bone density and ligamentous calcifications. These patients presented several difficult orthopaedic problems.
西日本整形・災害外科学会の論文