The effect of 2-thiophenecarbocylic acid (TCA) on fracture callus in early stage of HEBP (EHDP) induced rachitic rats.
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概要
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We have already shown that TCA promotes calcification of the thickened growth plate in the healing stage of HEBP-induced rachitic rats respectively. In this experiment female weanling Fisher-344 rats of 4 weeks of age were used and the experiment period was settled to be 2 weeks. Sixty mg/Kg body weight of HEBP was dosed subcutaneously, daily for the former 7 days and then 200, 400 or 600mg/kg body weight of TCA was given to the each rat of TCA group for the latter 7 days.In the result HEBP+TCA group showed prominent mineralization and calcification of newly formed bone and caltilage of the callus in comparison to rats treated with HEBP alone at 14 days after fracture.
- 西日本整形・災害外科学会の論文
著者
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江口 正雄
九州大学医学部整形外科学教室
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和田 文夫
九州大学医学部整形外科学教室
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島内 卓
九州大学医学部 整形外科
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柴田 堅一郎
九州大学医学部 整形外科
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川村 秀哉
九州大学医学部 整形外科
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井樋 直孝
九州大学医学部整形外科
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中島 勝也
九州大学医学部整形外科
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中家 一寿
九州大学医学部整形外科
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岸川 陽一
九州大学医学部整形外科
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松本 光司
九州大学医学部整形外科
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和田 文夫
九州大学医学部整形外科
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江口 正雄
九州大学医学部
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