:Influences of High Dose of Ethane-l-hydroxy-1, 1-Diphosphonate (EHDP) on Rat Bone Growth

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As we reported previously, with high dose of EHDP (60mg/kg per day for 7 days), the thickness of the epiphyseal growth plate was increased and osteoid tissue was accummulated in tibias of young female rats.In this paper, influences of this inhibited bone mineralization on bone growth were assessed roentogenologically, histologically and microangiographically.Our results were as follows.Until one week after treatment, inhibited bone mineralization was still continued. Calcification in increased epiphyseal growth plate was seen from two weeks after treatment and normal trabecullar pattern was identified from six weeks after treatment.Judging by growth curve of tibia and femur, half-time of growth suppression by EHDP in this system was about two weeks.
西日本整形・災害外科学会の論文