The effect of high dose of parent vitamin D3 and calcium gluconate on EHDP iduced rickets.

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We have reported that 1α, 25-(OH)2 D3 and calcium gluconate promote calcification in the widened growth plate of EHDP induced rachitic rats. In this report, EHDP induced rickets, the comparative study of the promotion of calcification by parent vitamin D3 and calcium gluconate was performed. Single administration of 30×101unit/kg vitamin D 3 promoted bone formation rather than calcification in the widened growth plate. On the other hand, consecutive administration of calcium gluconate enhanced calcification.With regard to the volume of hydroxy appatite in the widened epiphyseal plate, vitamin D3-injected groups were much larger than calcium-injected groups.These results suggested that the promotion of calcification by vitamin D3 was attributed to not only hypercalcemia but also the other effect of its own.
西日本整形・災害外科学会の論文