Treatment of the osteosacoma: Side effect of the chemotherapy.
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Since 1978, 30 patients with osteogenic sarcoma were admitted to our hospital and treated by surgery and adjuvant chemotheraphy. Patients received high dose methotrexate with citrovorum factor rescue, adriamycin, bleomycin-cyclophosphamide-actionmycin-D theraphy and cisplatium. Most disturbed side effects were myelodepression and alimentary tract complaint of nausea, vomiting and appetite loss. Myelodepression was prevented by considering the interval between administration of HD-MTX-CF rescue and adriamycin, dosage of ADM, BCD and good rescue of MTX. Usage of many effective antiemetic drugs reduced the alimentary side effects. These experiences of chemotherapy were the reasons that prolonged the survival of patients with osteogenic sarcoma.
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