A clinicopathologic study of three cases of pseudomalignant osseous tumor of soft tissue.

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Three cases of pseudomalignant osseous tumor of soft tissue are described. Histologically the lesion can not be differentiated from myositis ossificans, and sometimes might be misdiagnosed as osteosarcoma because of high cellularity, mitotic activities and osteoid formation. Clinical and laboratory findings are highly suggestive of inflammatory process. Two of the three cases were diagnosed primarily as pseudomalignant osseous tumor of soft tissue, however, the rest of a 5-year-old female was at first clinically as malignant soft tissue tumor, such as Ewing's sarcoma, rhabdomyosarcoma or synovial sarcoma on bases of severe inflammtory condition or immature calcification. The report of histopathologic examination of the biopsy specimen was osteosarcoma. The authors thought, however, that the diagnosis was still in doubt, because the morphological appearances of the cells showed slight nuclear atypia, and then the lesion was left undisturbed. Serial radiographs in following seventeen months showed regression of the lesion.Careful histological study, supplemented by clinical and rediological data, is necessary in order to arrive at a correct diagnosis and avoid misinterpreting it as a malignant tumor.
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