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概要

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• For the analysis of long-term dose, 45 rheumatoid patients who received D-penicillamine more than one year and 6 months were evaluated.Retrospectively, these were devided into two groups, one with effective maintenance and the other with the tendency of recurrence.In 19 of 45 patients, the therapeutic effect of D-penicillamine diminished within one year and 6 months.In the group with transient improvement, the improvement of LFT and Warrer-Rose reaction was slow and turned to get worse at about one year.The adverse reactions appeared in 53.3% of 45 patients. The protein-uria was most serious. One of 7 patients with protein-uric developed nephrotic syndrome, and heavy protein-uria persisted in 3 patients.

• 西日本整形・災害外科学会の論文

著者

• 野村 茂治

  九州大学医学部整形外科学教室

• 香月 一朗

  九州大学医学部整形外科

• 貝原 信紘

  九州大学医学部 整形外科

• 喜多 正鎮

  下関市立中央病院整形外科

• 近藤 正一

  九州大学医学部整形外科

• 秦 立比古

  九州大学医学部整形外科

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