Collagen-induced arthritis - Effect of cyclosporin A; Second report.:Effect of Cyclosporin A; Second Report
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The effect of the immunosuppressive agent Cyclosporin A (CS-A) on collagen-induced arthritis was invesgated in Sprague-Dawley rats. Treatment of CS-A in induction phase of type-II collagen immunization suppressed the development of arthritis as well as antibody titers and delayed-type hypersensitivity (DTH) skin reactions to type II collagen, possibly by interfering with helper T cells.However, treatment of CS-A in preclinical phase enhanced significantly the arthritis and DTH skin reaction with suppression of antibody titers, possibly by interfering with suppressor T cells.Treatment of CS-A in established arthritis enhanced or did not affect the lesions accompanied by an augmentation of DTH skin reactions.These patadoxical effect of CS-A to collagen-induced arthritis might be caused by the balance of two regulatory subpopulation of T cells, helper T cells and suppressor T cells.
- 西日本整形・災害外科学会の論文
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