Limb allograft in rats immunosuppressed with Cyclosporin. Autoradiographice examination of the articular cartilage.:autoradiographice examination of the articular cartilage

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As a whole-joint allograf t model, limb allografts with or without Cyclosporin (CS) treatment using three inbred rat strains, Fischer (F344; RT 11), Lewis (LEW; RT 11)and Brown Norway (BN; RT 1n), were performed and the articular cartilage was examined autoradiographically to determine the cell viability.In minor-mismatched allografts (LEW to F344), histologic examination and 35S-autoradiography demonstrated normal articular cartilage 16 weeks after operation with the use of CS, whereas, without CS treatment, severe degeneration and destruction of the articular cartilage were shown by 16 weeks.In major-mismatched allografts (BN to F344), the articular cartilage with CS treatment was normal histologically and autoradiographically 16 weeks after operation, while that without CS treatment was degenerated and destructed by 6 weeks.Our results indicate the possibility of clinical whole-joint allografts with the use of CS as well as other organ transplantations.
西日本整形・災害外科学会の論文