Electrophysiological effects of procaine in rabbit sino-atrial node cells.
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概要
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Effects of procaine (50-500 μg/ml) on membrane potential and currents were investigated using a two microelectrode-voltage clamp technique. Procaine reduced the action potential amplitude (APA), the maximum diastolic potential and the maximum rate of depolarization (V<SUB>max</SUB>) in a dose-dependent manner. At the same time, the action potential duration and the cycle length were prolonged. In voltage clamp experiments, procaine (50 μg/ml) did not affect the slow inward current (I<SUB>si</SUB>), but reduced the time-dependent outward current (I<SUB>k</SUB>). At concentrations higher than 100 μg/ml, procaine reduced both currents and the inward current activated by hyperpolarization in a dose-dependent manner. In 7 of 20 specimens, a low concentration of procaine (50 or 100 μg/ml) increased I<SUB>si</SUB> which enhanced the V<SUB>max</SUB> and APA, but did not increase I<SUB>k</SUB>. Procaine did not affect the steady-state inactivation of I<SUB>si</SUB> (f<SUB>∞</SUB>) and the activation of I<SUB>k</SUB> (p<SUB>∞</SUB>). The results suggest that the depressions of currents induced by procaine are due to a reduction in conductances of the current systems.
- 公益社団法人 日本薬理学会の論文
著者
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Satoh Hiroyasu
Department Of Chemistry School Of Science Kitasato University
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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