The lnfluenza Virus Persistent lnfection System and Live-Attenuated Vaccine
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概要
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The establishment of influenza virus persistent infection in vitro is one possible route to cultivate a live-attenuated virus. Durlng the course of persistent infection the infected cells remain alive and vims genes replicate continuously, leading to the inevitable emergence and accumulation of gene mutations, including point mutations and deletions. Virus recovered from cells infected persistently displays frequently growth properties which are distinct from the parental vifus, including slower growthrate, decreased cytopathology, altered virus enzymatic activity and temperature-sensitivity. Among viruses derived from the virus carrier culture, an avirulent temperature-sensitive mutant virus is unable to replicate in the lower respiratory tract of animals, but still retains the ability to elicit protective vifus-specific immune responses. Such a temperature-sensitive mutant virus is a promlsing candidate for clinical use as a live-attenuated vaccine.
- 岐阜医療科学大学の論文
著者
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Kimura Yoshinobu
Department Of Agricultural Science Faculty Of Agriculture Okayama University
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Kimura Yoshinobu
Department Of Medical Technology Gifu University Of Medical Science
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