Effect on Lipids in Liver and Serum, and Some Urinary Components of Dietary Supplement of Excess Lysine Given to Previously Starved or Non-starved Rats(Food & Nutrition)

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In order to obtain further information on the changes in liver lipids, either a basal or a lysine-excess diet was refed to previously starved rats or fed to previously non-starved rats. Liver lipid accumulation was observed in previously starved rats refed the lysine-excess diet for 7 days, but not in rats without previous starvation. The liver lipid did not accumulate with another 8 days' feeding (15 days' refceding). The addition of methionine alone or in combination with threonine to the lysine-excess diet had no effect on the liver lipid level. The decrease in serum triacylglycerol in rats refed the lysine-excess diet was preceded by lipid accumulation in the liver. Urinary potassium during the initial two days increased with refeeding and feeding. Marked excretion of orotate was observed for 2 days from the initiation of refeeding of the lysine-excess diet and it then decreased. Thus, such a marked increase in the urinary excretion of orotate might be associated with the stimulation of orotate biosynthesis and with lipid accumulation in the liver.
社団法人日本農芸化学会の論文
1989-09-23