Role of Ornithine Transport into Mitochondria in Urea Synthesis of Rats Treated with Thyroid Hormone
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of this study was to find whether or not the ornithine transport into mitochondria regulated urea synthesis when the thyroid status is manipulated. Experiments were done on three groups of rats: given 6-propyl-2-thiouracil (PTU, a thyroid inhibitor) without tri-iodothyronine (T3) treatment, treated with PTU+T3 or receiving neither PTU nor T3 (control). The urinary excretion of urea, liver concentration of ornithine and ornithine transport into isolated hepatic mitochondria in rats given PTU+T3 were significantly lower than in rats given PTU alone. Ornithine transport was significantly inhibited by the addition of lysine specifically. This response was achieved well within the physiological concentration of lysine. Compared with rats given PTU without T3 treatment, the liver concentration of lysine was significantly higher in rats treated with PTU+T3 and control rats. Ornithine transport into hepatic mitochondria was closely correlated with the excretion of urea. The results suggest that the greater ornithine transport in the hypothyroid (PTU alone) rats is likely to stimulate urea synthesis. A thyroid hor-mone-induced increase in lysine concentration may be at least partly responsible for the changes in ornithine transport into mitochondria.
- 財団法人 学会誌刊行センターの論文
著者
-
Hayase Kazutoshi
Department Of Home Economics Aichi University Of Education
-
Naganuma Yaeko
Deparmtent Of Home Economics Aichi University Of Education
-
Hayase K
Department Of Home Economics Aichi University Of Education
-
Yoshida Akira
Department Of Cardiology Kyoto National Hospital
-
Yoshida Akira
Department Of Agricultural Chemistry Nagoya University
-
NAGANUMA Yaeko
Department of Home Economics, Aichi University fo Education
-
HAYASE Kazutoshi
Department of Home Economics, Aichi University fo Education
関連論文
- The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction: Bladder Selectivity Based on In Vivo Drug–Receptor Binding Characteristics of Antimuscarinic Agents for Treatment of Overactive Bladder
- Dietary γ-Aminobutyric Acid Affects the Brain Protein Synthesis Rate in Ovariectomized Female Rats
- Physical Imaging Properties and Low-contrast Performance of a Newly Developed Flat-panel Digital Radiographic System
- PJ-464 Delayed Relaxation Detected by Regional Contraction Curve of Real-Time 3D Echocardiography Accurately Reflects Local Ischemia(Angina Pectoris, Clinical 2 (IHD) : PJ77)(Poster Session (Japanese))
- PE-462 Real-Time 3D Echocardiography Provides an Index of LV Diastolic Property : max dV/dt(Cardiac Function, Basic/Clinical 3 (M) : PE79)(Poster Session (English))
- PE-124 Real-Time 3D Echocardiography is a New Modality that Provides Accurate LV Volumetry : Comparisons with Conventional 2D-Echo Measurements(Echo/Doppler 5 (I) : PE21)(Poster Session (English))
- OJ-272 Quantitative Analysis of Regional Ventricular Motion by Real-Time 3D Echocardiography : Comparative Study to Semi-Quantifications by Conventional 2D-Echo Measurements and LVG(Echo/Doppler 10 (I) : OJ32)(Oral Presentation (Japanese))
- Secondary Malignant Fibrous Histiocytoma Following Refractory Langerhans Cell Histiocytosis
- Fludarabine-Mediated Circumvention of Cytarabine Resistance Is Associated with Fludarabine Triphosphate Accumulation in Cytarabine-Resistant Leukemic Cells
- Antibody epitope peptides as potential inducers of IgG antibodies against CD98 oncoprotein
- 34) CLINICAL STUDIES ON HEART FAILURE IN CARDIOMYOPATHY (V) DILATED CARDIOMYOPATHY WITH VARIOUS COMPLICATIONS
- 17)CLINICAL STUDIES ON HEART FAILURE IN CARDIOMYOPATHY (IV) HISTOLOGICAL CHARACTERISTICS OF MYOCARDITIS WITH HEART FAILURE : THE 7th CONFERENCE ON CARDIOMYOPATHY
- 15) CLINICAL STUDIES ON HEART FAILURE IN CARDIOMYOPATHY (III): MYOCARDITIS WITH HEART FAILURE
- The Transmission of Stress to Grafted Bone Inside a Titanium Mesh Cage Used in Anterior Column Reconstruction After Total Spondylectomy : A Finite-Element Analysis
- Reconstruction After Total Sacrectomy Using a New Instrumentation Technique : A Biomechanical Comparison
- Mechanical Evaluation of Reconstructed Structures after Total Sacrectomy and Their Improvement
- Surgical Strategy for Spinal Metastases
- ITCH is a putative target for a novel 20q11.22 amplification detected in anaplastic thyroid carcinoma cells by array-based comparative genomic hybridization
- GSD-03 IMPROVEMENT IN FATIGUE STRENGTH OF STEEL GEAR BY NEXT-GENERATION CAVITATION PEENING(GEAR STRENGTH AND DURABILITY, INCLUDING GEAR MATERIALS AND HEAT TREATMENT TECHNIQUES)
- Effects of Quantity and Quality of Dietary Protein on the Brain Polysome Profile in Aged Rats(Food & Nutrition Science)
- Lipid Accumulation in the Liver of Rats Fed a Soy Protein Isolate Diet with Excess Cystine, and its Prevention by Methionine or Choline
- Low-Temperature Growth of InN Films on (111)GaAs Substrates
- Crystal Structure and Orientation of Al_xIn_N Epitaxial Layers Grown on (0001) α-Al_2O_3 Substrates
- PE-186 Real-Time 3D Echocardiography Provides Reliable Measures of LV Function : Comparative Study with Quantitative Gated SPECT(Echo/Doppler 8 (I) : PE32)(Poster Session (English))
- Evaluation of in Stent Restenosis (ISR) using Profiling Curve Method with 16-row Multi Detector Computed Tomography (MDCT)(X-ray/CT/MRI/DSA 7 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-174 Evaluation of In-stent Restenosis (ISR) with 16-row Multi-detector Computed Tomography (MDCT)(X-ray/CT/MRI/DSA6 (I) : PE30)(Poster Session (English))
- Large Grain Growth in Cu(In, Ga)Se_2 Thin Films with Band Gap of around 1.4 eV by Thermal Crystallization in Saturated Se Vapors
- Preparation of Ordered Vacancy Chalcopyrite Thin Films by RF Sputtering from CuInSe_2 Target with Na_2Se
- Effect of Quality and Quantity of Dietary Protein on 4E-BP1 and S6K1 Phosphorylation of Brains in Aged Rats
- Elevation of the Hepatic Level of Albumin mRNA in Rats Fed a Non-protein Diet Supplemented with Sulfur-containing Amino Acids and Threonine
- Changes in N-Acetylglutamate Are Involved in Regulating Urea Synthesis in Rats Given a Low Gluten Diet Supplemented with L-Lysine, L-Methinone and L-Threonine
- Improvement of the Crystalline Quality of InN Layers Grown on Sapphire (0001) by Surface Nitridation
- The Growth Hormone Affects the Brain Protein Synthesis Rate in Hypophysectomized Aged Rats
- Effects of Adding Dietary Lysine to a Low Gluten Diet on the Brain Protein synthesis Rate in Aged Rats
- Effect of Dietary Protein Quality on the Brain Protein Synthesis Rate in Aged Rats
- Study on Surface Durability of Powder-Forged Rollers with Case-Hardening
- Role of N-Acetylglutamate Turnover in Urea Synthesis of Rats Given Proteins of Different Quality
- Changes in Tissue Protein Synthesis Are Involved in Regulating Urea Synthesis in Rats Given Proteins of Different Quality
- Effect of a Thyroid Hormone Treatment on Brain Protein Synthesis in Rats
- Lipid Alterations in the Liver and Serum of Rats in Histidine-Excess and Copper Deficiency
- Effect on Liver and Serum Lipids in Rats of Dietary Additions of Fibers and Cholestyramine to a Cystine-excess Diet(Food & Nutrition)
- Effect of Exercise on Tissue Protein Synthesis in Rats
- Subarachnoid Hemorrhage Caused by Aspergillus Aneurysm as a Complication of Transcranial Biopsy of an Orbital Apex Lesion : Case Report
- 2-O-Octadecylascorbic Acid with No Vitamin C Activity in ODS-od/od Rats(Food & Nutrition)
- A Low Protein Diet Increases 4-Nitrophenol-UDPglucuronosyltransferase but Decreases Chloramphenicol-UDPglucuronosyltransferase Activity and mRNA Level in Livers of Rats Treated with Polychlorinated Biphenyls
- Microhardness of Indium Nitride Single Crystal Filrms
- Fabrication of ZnTe Light-Emitting Diodes Using Bridgman-Grown Substrates
- PE-100 Usefulness of 16-row Multidetector Computed Tomography (MDCT) as a Modality for Screening of Outpatients' coronary Artery Disease (CAD)(CT/DSA-3 (I) PE17,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circul
- GSD-18 EFFECT OF SURFACE MODIFIED LAYER ON ROLLING FATIGUE STRENGTH(GEAR STRENGTH AND DURABILITY)
- Effects of Dietary Excess Histidine and Varying Levels of Copper on the Metabolism of Lipids and Minerals in Rats
- Effect of a Dietary Excess of Histidine and Subsequent Starvation on Serum Lipids in Rats(Food & Nutrition)
- Temperature Dependence of Band Gap Change in InN and AlN
- Electrothermal Effects in Chalcogenide Glass Semiconductors
- Effect of the Quality of Dietary Amino Acids Composition on the Urea Synthesis in Rats
- GSD-12 OBSERVATION OF CRACK PROPAGATION BEHAVIOR IN STEEL ROLLER UNDER SLIDING-ROLLING CONTACT FOR EVALUATING ITS FATIGUE LIFE(GEAR STRENGTH AND DURABILITY)
- GSD-9 EFFECT OF SHOT PEENING ON SURFACE DURABILITY OF PLASMA CASE-HARDENED SINTERED POWDER METAL ROLLERS(GEAR STRENGTH AND DURABILITY)
- Rapid Development of a Papillary Fibroelastoma in the Aortic Valve : Report of a Case
- Effects of Administration of an Extract of Tu-chung Leaf (Eucommia ulmoides, Oliver) on Muscle Protein Synthesis in Mice(Food & Nutrition)
- High Reverse Currents of GaSb and GaAs Tunnel Diodes
- 5-Hydroxytryptamine Receptors, Especially the 5-HT_4 Receptor, in Guinea Pig Urinary Bladder
- Alteration of Oxidative Phos phorylation in Uremia
- Liver-specific Induction of NADPH-generating Enzymes by Polychlorinated Biphenyls in Rats
- Role of N-Acetylglutamate Turnover in Urea Synthesis by Rats Treated with the Thyroid Hormone
- Role of Ornithine Transport into Mitochondria in Urea Synthesis of Rats Treated with Thyroid Hormone
- Role of Amino Acid-catabolizing Enzymes in Urea Synthesis for Rats Treated with the Thyroid Hormone
- Liver-specific Induction of Ribosomal Protein Gene Expression by Amino Acid Starvation in Rats
- Role of Ornithine in the N-Acetylglutamate Turnover in the Liver of Rats
- Chemiluminescence Emission of C_2, CH and OH Radicals from Opposed Jet Burner Flames
- Structure of Opposed Jet Flame and NO_x Formation
- Characteristics of Mixture Turbulence and Structure of Opposed Jet Burner Flames
- Tunneling Spectroscopic Study of the Impurity Band of (000) Valley of Germanium
- Tunneling through Band Tail States
- Uniaxial Stress Effect on Subsidiary Band Minima of GaSb from Zero Bias Conductance Anomaly
- Uniaxial Stress Effect on (000) and (100) Conduction-Band Minima of Germanium
- Neurosteroids stimulate G protein-coupled sigma receptors in mouse brain synaptic membrane
- An X-Ray Diffraction Method for Characterization of Several Lattice-Matched Heteroepitaxial Films
- GLE-11 INFLUENCE OF BASE OIL VISCOSITY, VISCOSITY INDEX IMPROVER, AND ADDITIVES OF LUBRICATING OIL ON ROLLING CONTACT FATIGUE STRENGTH OF STEEL ROLLER(GEAR LUBRICATION AND EFFICIENCY)
- A case of splenosis : diagnosis with contrast-enhanced ultrasonography
- Intervalley Transfer in Uniaxially Strained n-Type Ge
- Effect of Supplementing Methionine and Threonine to a Non-protein Diet on the Induction of Enzymes by Polychlorinated Biphenyls in Rats(Food & Nutrition)
- Uniaxial Stress Effect on p^+-n Si-Ge Alloyed Heterojunction Characteristics
- Transport Mechanism of Alloyed p^+-n Heterojunctions with Relatively Heavy Doping
- Role of Ornithine in Urea Synthesis in Rats Treated with Thyroid Hormone
- Effect of Dietary γ-Aminobutyric Acid on the Brain Protein Synthesis Rate in Hypophysectomized Aged Rats
- Anomalous Junction Capacitance in Tunnel-Diodes
- Barrier Capacitance and Built-in Voltage of Tunnel Diodes
- Role of Ornithine Transport into Mitochondria in Urea Synthesis of Rats Treated with Thyroid Hormone
- Effect on Lipids in Liver and Serum, and Some Urinary Components of Dietary Supplement of Excess Lysine Given to Previously Starved or Non-starved Rats(Food & Nutrition)
- Extinction of Wrinkled Laminar Flame and Existence of Distributed Reaction Zone
- Increase in the Level of Skeletal Muscle α-Actin mRNA in Rats Fed a Non-protein Diet Supplemented with Cystine and Threonine
- A Case of Drug-Induced Hypersensitivity Syndrome-Like Symptoms Following HHV-6 Encephalopathy
- The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction : Bladder Selectivity Based on In Vivo Drug-Receptor Binding Characteristics of Antimuscarinic Agents for Treatment of Overactive Bladder
- Structure of Opposed Jet Turbulent Premixed Flames
- 旨味調味料の味覚を識別するための複合イオン選択性電極システムの開発と基礎研究
- Defects Induced by Uniaxial Stress in GaP Red LEDs
- Neurobiology of the Edg2 Lysophosphatidic Acid Receptor
- Nutritional Significance of Dietary Cystine for Maintaining the Hepatic Albumin mRNA Level in Rats Fed on a Soybean Diet
- A Case of Thyroid Storm with Multiple Organ Failure Effectively Treated with Plasma Exchange
- Dietary Ornithine Affects the Tissue Protein Synthesis Rate in Young Rats
- Effect of Dietary Ornithine on the Brain Protein Synthesis Rate in Hypophysectomized Aged Rats