Guanidinated Casein Hydrolysate Stimulation of Cholecystokinin Release via Pancreatic Enzyme-and Cholinergic-independent Mechanisms in Rats
スポンサーリンク
概要
- 論文の詳細を見る
We had demonstrated that a peptic hydrolysate of guanidinated casein that is made from casein by the conversion of lysine to homoarginine stimulated pancreatic exocrine secretion in rats with chronic bile-pancreatic juice (BPJ) diversion from the proximal small intestine. This modified protein also stimulated cholecystokinin (CCK) release from dispersed rat intestinal cells. In this study, we found that guanidinated casein hydrolysate stimulates CCK release in chronic BPJ-diverted rats with cholinergic control blocked by atropine. Intraduodenal guanidinated casein hydrolysate increased portal plasma CCK concentration and pancreatic secretion in atropine-treated BPJ-diverted rats. In contrast, the portal plasma CCK concentration was not increased by intact casein hydrolysate. We conclude that guanidinated casein hydrolysate directly stimulates CCK release from the intestine via some cholinergic-independent mechanism, and an increase of the pancreatic exocrine secretion is regulated by CCK released by guanidinated casein hydrolysate. A guanidyl residue is likely to be involved in this control.
- 社団法人日本農芸化学会の論文
- 1999-06-23
著者
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HARA Hiroshi
Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University
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Nishi T
Department Of Bioscience And Chemistry Faculty Of Agriculture Hokkaido University
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NISHI Takashi
Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University
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AOYAMA Yoritaka
Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University
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Nishi Takashi
Department Of Bioscience And Chemistry Faculty Of Agriculture Hokkaido University
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Aoyama Yoritaka
Department Of Agricultural Chemistry School Of Agriculture Nagoya University
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Aoyama Yoritaka
Department Of Bioscience And Chemistry Faculty Of Agriculture Hokkaido University
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Hara Hiroshi
Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo Noko University
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HARA Hiroshi
Department fo Bioscience and Chemistry, Faculty of Agriculture
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