家畜における薬物冬眠の研究(第一報) : 家畜における臨床所見 : 特に体温・脈博・呼吸を中心として

概要

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Chlorpromazine, one of the representative pharmacological hibernation drugs, has been used in the present experiments in domestic animals especially in dogs. We have observed the clinical symptoms, especially the temperature, pulse and respiration of the dog after a single use of this drug by the intravenous or intramuscular injection. The results of our experiments are summarized as follows : 1) In general, temperature lowers immediately after injection, and the grade of abatement of the temperature is remarkably influenced by the room temperature. Pulse increases temporarily after injection and is followed by the depressed condition for a few hours. Respiration is generally depressed regardless of the administrated dose. 2) The sedative, tranquilizing and narcotic effects have been recognized by many reporters. But these effects are not observed satisfactorily in our single use of this drug. So we bilieve that this drug is desirable to be used as a combination or potentiated anesthesia. 3) Lethal dose is not yet shown but we suppose that it may be influenced by the kind of animals, individual variation and the room temperature.
鹿児島大学の論文