慢性関節リウマチにおけるコリンエステラーゼ活性の研究

概要

論文の詳細を見る
Cholinesterase activities in plasma (pseudo-ChE) and red blood cells (true-ChE) were determined in 24 patients with rheumatoid arthritis, in 8 patients with osteoarthritis deformans and in 37 normal individuals, according to the modified method of Ellman. There was a statistically significant decrease of the pseudo-ChE activity in patients with rheumatoid arthritis, as compared with that in other groups. The activity of the pseudo-ChE in patients with rheumatoid arthritis seemed to have some relation with the duration and the stage of the disease, that is the longer the duration and the more advanced the disease, the lower the pseudo-ChE activity. Moreover, there was a statistically significant correlation between the pseudo-ChE activity and the activity of rheumatoid arthritis, the more active the disease, the lower the pseudo-ChE activity. The true-ChE activity, however, has no relationships with any conditions in this disease. In patients with rheumatoid arthritis on prednisolone, these same results were observed. Therefore, this study suggests that the pseudo-ChE activity could be used as an index of the severity and the activity of rheumatoid arthritis.
北里大学の論文
1973-12-31