New Chromogenic Substrates for the Assy of Esterases-Acetates and Butyrates of Phenolic Naphthylazo Compounds with Sulfonic Acid Group
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概要
- 論文の詳細を見る
Eight esters (acetates and butyrates) of four phenolic naphthylazo compounds with sulfonic acid group (s) were synthesized and assessed as water-soluble chromogenic substrates for the assay of esterases. The absorption maxima of azo compounds produced enzymatically from these esters occur at wavelengths about 100 nm longer than those of the esters and their molar absorptivities are, higher than those of the esters. Investigations on the substrate specificities of these esters revealed, that all the esters are hydrolyzed by carboxyl esterase- and aryl esterase-mediated reactions, and butyrates of m-(4-hydroxy-1-naphthylazo) benzenesulfonic acid and Azorubin should be particularly useful as substrates for cholinesterase and aryl esterase, respectively.
- 社団法人日本薬学会の論文
- 1983-01-25
著者
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大倉 洋甫
Faculty Of Pharmaceutical Sciences Kyushu University
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財津 潔
Faculty of Pharmaceutical Sciences, Kyushu University 62
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財津 潔
Faculty Of Pharmaceutical Sciences Kyushu University 62
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蒲池 信一
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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若林 清重
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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蒲池 信一
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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大倉 洋甫
Faculty Of Pharmaceutical Science Kyushu University
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大倉 陽甫
Faculty Of Pharmaceutical Sciences Kyushu University Katakasu Fukuoka
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若林 清重
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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