A New Ligand for Europium(III) That Forms a Stable Fluorescent Complex in Aqueous Solution
スポンサーリンク
概要
- 論文の詳細を見る
A new macrocyclic ligand for Eu^<3+>, 24,30-diphenyl-8,19-(1,21 : 4,6 : 10,12 : 15,17-tetraetheno-8,9,19,20-tetrahydro-7H, 18H-dibenzo[b, k][1,4,7,10,13,16]hexaazacyclooctadecine)diacetic acid (1), was synthesized and its fluorescence characteristics were examined, particulary to compare with 4,7-bis(chlorosulfophenyl)-1,10-phenanthroline-2,9-dicarboxylic acid (BCPDA) that has proved to be useful as a label in time-resolved fluoroimmunoassays. The complex of macrocycle 1 with Eu^<3+> was found to have a higher fluorescence intensity as well as a longer fluorescence lifetime than that of BCPDA.
- 社団法人日本薬学会の論文
- 1992-12-25
著者
-
大倉 洋甫
Faculty Of Pharmaceutical Sciences Kyushu University
-
佐藤 尚文
Biosciences Research Laboratory Mochida Pharmaceutical Co. Ltd.
-
寺沢 秀之
Biosciences Research Laboratory Mochida Pharmaceutical Co. Ltd.
-
堀口 大吉
Dojindo Laboratories
-
佐々本 一美
Dojindo Laboratories
-
望月 博
Biosciences Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
-
片山 佳樹
Dojindo Laboratories
-
大倉 洋甫
Faculty Of Pharmaceutical Science Kyushu University
-
望月 博
Biosciences Research Laboratory Mochida Pharmaceutical Co. Ltd.
-
大倉 洋甫
Faculty of Pharmaceutical Sciences, Kyushu University
関連論文
- Water-Soluble Carrier Proteins Having Carboxyl Spacer Groups
- High-Performance Liquid Chromatographic Separation of Citraconylinsulins and Preparation of Gly^Phe^-Dicitraconylinsulin
- Heterobifunctional Reagents for Cross-Linking of Sugar with Protein
- Determination of L-3,4-Dihydroxyphenylalanine in Plasma and Urine by High-Performance Liquid Chromatography with Fluorescence Detection(Analytical,Chemical)
- Fluorimetric Assay for Catechol-O-methyltransferase
- Fluorimetric Assay for Dopamine β-Hydroxylase in Rat Plasma
- A Sensitive Fluorometric Assay of Human Platelet Monoamine Oxidase and Its Application to Assessment of Monoamine Oxidase Inhibitor
- A Novel Fluorometric Assay Method of Dopamine-β-hydroxylase Activity in Human Serum
- HPLC-蛍光検出による人尿中イミダゾール酢酸及びN^τ-及びN^π-メチルイミダゾール酢酸の同時定量(発表論文抄録(1987年))
- Pre-column Fluorescence Derivatization High-Performance Liquid Chromatography of Opioid Peptides in Rat Brain and Its Use for Enzymatic Peptide Characterization
- A Practical Reagent for Reversible Amino-Protection of Insulin, 3,4,5,6-Tetrahydrophthalic Anhydride
- Preparative and Analytical Separations by High-Performance Liquid Chromatography and Capillary Electrophoresis of the Products from the Reaction of Insulin with exo-3,6-Epoxy-1,2,3,6-tetrahydrophthalic Anhydride
- Effect of Spacer Groups Connecting Insulin with Fluorophore in Gly(A1)-sulfobenzoxadiazole-Labeled Insulins on the Immunoreactivity toward Anti-insulin Antibody
- Preparation of Fluorescence Labeled Insulins, Sulfobenzoxadiazolyl-insulins, for Fluorescence Immunoassay
- Evaluation of the Numbers of Functional Groups Introduced into Horseradish Peroxidase in Reactions with Four Heterobifunctional Reagents
- Preparation of Acetylmercapto-3-carboxypropanol Insulins Using Preparative High-Performance Liquid Chromatography on an Anion-Exchange Column
- Preparation of S-Acetylthioglycoloyl Insulins Based on Separation by Anion-Exchage High-Performance Liquid Chromatography
- Solid-Phase Enzyme-Immunoassay of Anti-Insulin Antibiodies : Effect of Labeling Site in Insulin and of Labeled Number of Horseradish Peroxidase on the Assay Sensitivity
- Assay of Adenosine Deaminase in Serum by Flow-Injection Analysis with Fluorescence Detection
- Preparation of [3-(2-Phyridyldithio)propionoyl]insulins and Horeseradish Peroxidase-Insulin Conjugates by High-Performance Liquid Chromatographic Separation
- Assay of Purine Nucleoside Phosphorylase in Erythrocytes by Flow-Injection Analysis with Fluorescence Detection(Analytical,Chemical)
- Fluorimetric Assay for Hydrolytic Activity of Cholesterol Esterase in Rat Tissues
- New Chromogenic Substrates for the Assy of Esterases-Acetates and Butyrates of Phenolic Naphthylazo Compounds with Sulfonic Acid Group
- Rapid Enzyme Immunoassay for Human Choriogonadotropin in Serum using Horseradish Peroxidase as a Label
- Photo-decomposition of Captan and Difolatan
- 自動カラムスイッチング高速液体クロマトグラフィーによる血清中のアンピシリンの定量(品質管理・工程管理のための分析化学)
- A Fluorescent DNA Probe Prepared by the Direct Derivatization of the Sugar Moiety for Hydridization Assay
- Precolumn Derivatization of Nucleotides Based on Fluorescent Carbamate Formation on the Sugar Moieties in High-Performance Liquid Chromatogragphy
- Determination of 2', 3'-Dideoxyinosine and 2', 3'-Dideoxyadenosine in Rat Plasma by High-Performance Liquid Chromatography with Precolumn Fluorescence Derivatization
- 3-Bromomethyl-6,7-methylenedioxy-1-methyl-2(1H)-quinoxalinone as a Highly Sensitive Fluorescence Derivatization Reagent for Carboxylic Acids in High-Performance Liquid Chromatography
- 1,2-Diamino-4,5-methylenedioxybenzene as a Highly Sensitive Fluorogenic Reagent for α-Keto Acids(Analytical,Chemical)
- An Ultramicro Fluorimetric Determination of Total Ascorbic Acid in Human Serum Using 1,2-Diamino-4,5-dimethoxybenzene
- Fluorescent Products of Reaction between α-Keto Acids and 1,2-Diamino-4,5-dimethoxybenzene
- Fluorescent Product in the Determination of Aromatic Aldehydes with 4,5-Dimethoxy-1,2-diaminobenzene
- Mechanism of the Color Reaction between Aldehyde and Diazotized Aromatic Amine. II. Color Reaction Product of Benzaldehyde with Diazotized Sulfanilamide
- A Novel Time-Resolved Fluoroimmunoassay Using a Macrocyclic Europium Ligand as a Label
- A New Ligand for Europium(III) That Forms a Stable Fluorescent Complex in Aqueous Solution
- A New Photometric Method for the Determination of Serum Glutamate Pyruvate Transaminase Activity using Pyruvate and Glutamate as Substrates
- Spectrophotometric Assay for Lipase in Serum Using a Chromogenic Substrate, Orange I Laurate
- A New Sulfonated Tetrazolium Salt That Produces a Highly Water-Soluble Formazan Dye
- Diaminodiphenylmethane Derivatives as a New Chromogenic Hydrogen Donor in Peroxidase-Catalyzed Oxidation Reaction with Hydrogen Peroxide
- Fate of Hydralazine in Man. II. Formation of Tetrazolo [5,1-α] phthalazine in Vivo and Inhibition of Monoamine Oxidase by This Metabolite
- Fluorimetric Determination of Hexose with 5-Hydroxy-1-tetralone using Cupric Sulfate as an Accelerator of the Reaction
- Determination of Sulthiame in Plasma by High-Performance Liquid Chromatography
- 1,2-Diarylethylenediamines as Pre-column Fluorescence Derivatization Reagents in High-Performance Liquid Chromatographic Determination of Catecholamines in Urine and Plasma
- Simultaneous Determination of 2-Deoxy-D-glucose and D-Glucose in Rat Serum by High-Performance Liquid Chromatography with Post-Column Fluorescence Derivatization
- Fluorescence Reaction of Ribonucleosides and Ribonucleotides with 1,2-Bis(4-methoxyphenyl)ethylenediamine
- High-Performance Liquid Chromatographic Assay for Catechol-O-methyltransferase in Human and Rat Erythrocyte Membrane and Soluble Fractions, and Rat Tissues
- A New Photometric Assay Method of Serum Glutamate Dehydrogenase
- A New Colorimetric Method for the Determination of Serum Isocitric Dehydrogenase Activity
- Phosphorescence from 3,4-Dihydroxyphenyl Derivatives in Basic Solution and Its Use for the Assay of Epinephrine and Norepinephrine in Urine
- An Ultramicro Phosphorimetric Assay for Alkaline and Acid Phosphatase Activities
- Phosphorimetric Assay for 3-Methoxy-4-hydroxyphenylethyleneglycol in Urine
- Mechanism of the Color Reaction of Active Methylene Compounds with 1,3,5-Trinitrobenzene Derivatives. XI. The Jaffe Reaction
- Mechanism of the Color Reaction of Active Methylene Compounds with 1,3,5-Trinitrobenzene Derivatives. VIII. Interaction of Monoand Dihydroxylated Species (1 : 1 and 1 : 2 Complexes) derived from 1,3,5-Trinitrobenzene and Hydroxide Ion with Acid
- Reaction Products of 2-Oxoglutaric Acid with Diazotized Sulfanilamide
- A Sensitive Enzymatic Method for the Fluorimetric Assay of Cholesterol in Serum and High-Density Lipoprotein
- An Ultramicro Enzymatic Method for the Fluorimetric Determination of Uric Acid in Serum
- A New Fluorometric Assay for Human Serum Monoamine Oxidase
- Studies on Fluorometric Determination of Aromatic Aldehydes with 1,2 Diaminonaphthalene. II. On the Reaction Products of Benzaldehyde, Cinnamaldehyde, and Pyruvic Acid
- 醸造酢固形成分の血清コレステロール, 赤血球変形能に及ぼす効果
- Color Reaction Mechanism of Anthrone with Sugars. (2). Some Reaction Products of Furfural with Anthrone (Organic Analysis. XLVII)
- β-Diketone Derivative That Forms a Fluorescent Eu^ Complex in an Aqueous Solution
- Preparation and Evaluation of Fatty Acid Esters of 2-(4-Hydroxyphenyl)-4,5-diphenylimidazole as Fluorescent Substrates for Measurement of Lipase Activity
- Preparation and Evaluation of Fatty Acid Esters of Fluorescent p-Substituted Phenols as Substrates for Measurement of Lipase Activity(Analytical,Chemical)
- 自動カラムスイッチング高速液体クロマトグラフィーによる血しょう及び血清中セファレキシンの定量
- Determination of Nifedipine in Plasma by High-Performance Liquid Chromatography
- A Sensitive Fluorimetric Assay for Human Serum Monoamine Oxidase Activity
- Fluorimetric Assay of Histamine N-Methyltransferase by High-performance Liquid Chromatography
- Chemiluminescence Assay of N-Acetyl-β-D-glucosaminidase in Urine Using o-Aminophthalylhydrazido-N-acetyl-β-D-glucosaminide
- A New Chemiluminogenic Substrate for N-Acetyl-β-D-glucosaminidase, 4'-(6'-Diethylaminobenzofuranyl)phthalylhydrazido-N-acetyl-β-D-glucosaminide
- A Chemiluminogenic Substrate for N-Acetyl-β-D-glucosaminidase, o-Aminophthalylhydrazido-N-acetyl-β-D-glucosaminide
- New Water-soluble Hydrogen Donors for the Enzymatic Photometric Determination of Hydrogen Peroxide. II. N-Ethyl-N-(2-hydroxy-3-sulfopropyl) aniline Derivatives
- Mechanism of the Color Reaction between m-Dinitrobenzene and Alkali Cyanide. II. Color Reaction Products of 2,4-Dinitroaniline with Potassium Cyanide (Organic Analysis. LXXII)
- 醸造酢の人体の血中脂質, 血液レオロジーに及ぼす影響
- Sensitive Fluorimetric Assay for Human Thyroid Peroxidase Using p-Cresol as a Substrate
- テトラリン誘導体の研究(第2報)オキシテトラリン及びオキシテトラロンの紫外吸収スペクトル
- High-Performance Liquid Chromatographic Determination of Peptides Released by Tryptic Degradation from Opioid Peptide Precursors in Rat Brain
- 有機定性分析(第5報) : 芳香族炭化水素及びエーテルのベーパークロマトグラフィー
- Tetralin誘導体の研究(第1報) : 試験管内に於ける抗菌作用
- m-ジニトロベンゼン誘導体とシアン化アルカリの呈色反応機構(第3報) : 2,4-ジニトロフェノールとシアン化カリウムの反応生成物
- Mechanism of the Color Reaction between m-Dinitrobenzene Derivatives and Alkali Cyanide. (I). Some Reaction Products of m-Dinitrobenzene with Potassium Cyanide (Organic Analysis. LXVIII)
- イソチオシアネートの新比色定量法 : アプラナ科植物の研究, 第1報
- Mechanism of the Color Reaction of Pyruvic Acid with p-Dimethylaminobenzaldehyde. I. On the Reaction Products of Pyruvic Acid and p-Dimethylaminobenzaldehyde
- Colorimetric Determination of Pyruvic Acid with p-Dimethylaminobenzaldehyde
- Automated Determination of Urea Nitrogen in Serum with Diacetyl Monoxime-Glucuronolactone Reagent (Organic Analysis. LXXIII)
- ジアセチルモノオキシム-グルクロノラクトン試薬による血液中の尿素窒素の微量定量(有機分析 第63報)
- Organic Analysis. XXXV. Mechanism of the Color Reaction between Hexose and Thymol. (1).
- Organic Analysis. XIII. Estimation of Hexose with 5-Hydroxy-1-tetralone.
- Organic Analysis. X. Reaction Mechanism of 5-Hydroxytetralone with Glucose.
- 有機分析(第7報)5-オキシテトラロンによるヘキソーゼの新螢光反応
- 現代に生きる日本の伝統技術(2)醸造(つく)る--機能性食品としての"純米黒酢"
- 機器分析法の基礎知識--蛍光・りん光法
- 生体の超微量物質を追う--HPLC-蛍光検出法
- Mechanism of the Color Reaction of Active Methylene Compounds with 1,3,5-Trinitrobenzene Derivatives. VII. Color Reactions of Acetophenone with 1,3,5-Trinitrobenzene in Methanol and Methanol-Water Mixtures
- Mechanism of the Color Reaction of Active Methylene Compounds with 1,3,5-Trinitrobenzene Derivatives. VI. A Protonated Species of the Meisenheimer Type Compound derived from Picric Acid and Acetone
- Mechanism of the Color Reaction of Active Methylene Compounds with 1,3,5-Trinitrobenzene Derivatives. V. A New Type and the Meisenheimer Type Coloring Matters of the Janovsky Reaction of Acetophenone and 1,3,5-Trinitrobenzene
- Mechanism of the Color Reaction of Active Methylene Compounds with 1,3,5-Trinitrobenzene Derivatives. IV. Color Reaction of Picric Acid and Acetone under the Janovsky Conditions
- Determination of 3-Hydroxybutyric Acid in Blood via Acetone with Trinitrobenzene (Organic Analysis. LX)
- Mechanism of the Color Reaction of Active Methylene Compounds with 1,3,5-Trinitrobenzene Derivatives.III. The Color Reactions of Cyclohexanone, and Acetophenone, with 1,3,5-Trinitrobenzene