3-Bromomethyl-6,7-methylenedioxy-1-methyl-2(1H)-quinoxalinone as a Highly Sensitive Fluorescence Derivatization Reagent for Carboxylic Acids in High-Performance Liquid Chromatography

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概要

• 論文の詳細を見る

• 3-Bromomethyl-6,7-methylenedioxy-1-methyl-2(1H)-quinoxalinone was found to be a highly sensitive fluorescence derivatization reagent for carboxylic acids in high-performance liquid chromatography. Its reaction conditions were optimized for various linear C_3-C_<20> saturated fatty acids. The reagent reacts with the fatty acids in acetonitrile in the presence of 18-crown-6 and potassium carbonate to produce the corresponding fluorescent derivatives, which can be separated on a reversed-phase column, Radial-Pak C_<18> cartridge, by gradient elution with 35-100% (v/v) aqueous methanol. The detection limits for the acids were 0.2-0.8 fmol for an injection volume of 10μl.

• 社団法人日本薬学会の論文
• 1988-06-25

著者

• 大倉 洋甫

  Faculty Of Pharmaceutical Sciences Kyushu University

• 中村 優

  福岡大学薬学部薬品分析学教室

• 中村 優

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 原 周司

  Faculty Of Pharmaceutical Science Fukuoka University

• 山口 政俊

  Faculty Of Pharmaceutical Science Fukuoka University

• 竹廣 敦

  Faculty of Pharmaceutical Science, Fukuoka University

• 竹廣 敦

  Faculty Of Pharmaceutical Science Fukuoka University

• 大倉 洋甫

  Faculty Of Pharmaceutical Science Kyushu University

• 大倉 陽甫

  Faculty Of Pharmaceutical Sciences Kyushu University Katakasu Fukuoka

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