High-Performance Liquid Chromatographic Separation of Citraconylinsulins and Preparation of Gly^<Al>Phe^<Bl>-Dicitraconylinsulin
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概要
- 論文の詳細を見る
A method for the mutual separation of six citraconylated porcine insulins and intact insulin from the reaction mixture of insulin with citraconic anhydride is described, based upon anionexchange high-performance liquid chromatography on a TSK IEX-540 DEAE column. The method permits the preparative isolation of citraconylinsulins. The optimal reaction conditions for the preparation of Gly^<Al>Phe^<Bl>-dicitraconylinsulin, a useful starting material for the preparation of Lys-B29 modified insulin derivatives, were also investigated.
- 社団法人日本薬学会の論文
- 1985-03-25
著者
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大倉 洋甫
Faculty Of Pharmaceutical Sciences Kyushu University
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山田 秀徳
Faculty Of Pharmaceutical Sciences Kyushu University
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財津 潔
Faculty of Pharmaceutical Sciences, Kyushu University 62
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細谷 博幸
Faculty of Pharmaceutical Sciences, Kyushu University 62
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林 要司
Faculty of Pharmaceutical Sciences, Kyushu University 62
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財津 潔
Faculty Of Pharmaceutical Sciences Kyushu University 62
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細谷 博幸
Faculty Of Pharmaceutical Sciences Kyushu University
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大倉 洋甫
Faculty Of Pharmaceutical Science Kyushu University
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大倉 陽甫
Faculty Of Pharmaceutical Sciences Kyushu University Katakasu Fukuoka
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林 要司
Faculty Of Pharmaceutical Sciences. Kyushu University
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山田 秀徳
Faculty Of Pharmaceutical Sciences Kyushu University 62
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