Reaction of 1-Nitro-2,2-bis(methylthio)ethylene. II. Synthesis of 2-Hydroxyimino-3-methylthio-5-oxopyrroline Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
Methyl 1-cyano-2-methylthio-3-nitrocrotonate, 1-phenyl-2-methylthio-3-nitrocrotonitrile, and 1-cyano-2-methylthio-3-nitrocrotonamide, which contain cyano and nitro group at 1-and 3-position, were refluxed in MeOH or EtOH to give 2-hydroxy-3-methylthio-5-oxopyrroline derivatives, with ring closure between cyano and nitro group. The reaction of methyl 1-cyano-2-methylthio-3-nitrocrotonate with equimolar amount of amine gave methyl 2-hydroxy-3-amino-5-oxopyrroline-4-carobxylate which was replaced methylthio with amino group and with ring closure. However, with excess amine gave amine salt of nitro group, and also replaced with methylthio group. The raction of pyrroline derivatives with active methylene compounds gave the corresponding substituted compounds.
- 社団法人日本薬学会の論文
- 1973-08-25
著者
-
松田 芳郎
School Of Pharmaceutical Sciences Nagasaki University
-
曽根 正勝
長崎大学薬学部
-
松田 芳郎
Faculty of Pharmaceutical Sciences, Nagasaki University
-
富永 義則
Faculty of Pharmaceutical Sciences, Nagasaki University
-
小林 五郎
Faculty of Pharmaceutical Science, Nagasaki University
-
夏木 令子
長崎大学薬学部
-
夏木 令子
Faculty of Pharmaceutical Sciences, Nagasaki University 1-14 Bunkyo-machi, Nagasaki
-
曾根 正勝
Faculty of Pharmaceutical Sciences, Nagasaki University
-
富永 義則
長崎大 薬
-
富永 義則
Faculty Of Pharmaceutical Sciences
-
夏木 令子
Faculty Of Pharmaceutical Sciences Nagasaki University
関連論文
- 複素環化合物およびKetenethioacetal誘導体を中心とする有機化合物の抗腫瘍性スクリーニング
- Indole誘導体の抗腫瘍性スクリーニング
- Thermal Reaction of Imidazolium N-Vinylimino Ylides : Formation of Mesomeric Betaines, Imidazopyridaziniumides, via Back-Donated 1,6-Cyclization
- Imidazo[1,2-a]pyridine誘導体の合成とその反応
- Thiazolo[3,2-α]pyridine誘導体の合成とその反応
- 電子供与基としてDimethylaminoindolizine骨格を持つメチン系色素の合成
- Studies on Quinolizine Derivatives. XXIV. : Catalytic Hydrogenation of Cycl[3.3.3]azines
- Studies on Quinolizine Derivatives. XXIII. : Synthesis and Reactions of Methylthioazacycl[3.3.3]azines
- Studies on Quinolizine Derivatives. XXII. : Syntheses and Properties of 2-Phenylazacycl[3.3.3]azine Derivatives
- Quinolizine誘道体の研究(第21報)Cyclazine誘道体の合成 その15