Sulfonyl Ketenethioacetal(第3報)活性メチレン化合物類との反応

概要

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Sulfonyl ketenethioacetals (IIa-e), 1-substituted (R^1) 2,2-bis (methylthio)-1-sulfonyl-(R^2) ethene (a : R^1=SO_2-Ph, R^2=COMe ; b : R^1=SO_2-Ph-Me (p), R^2=CN ; c : R^1=SO_2-Ph-Me (p), R^2=CN ; d : R^1=SO_2-Ph-Me (p), R^2=COOMe) reacted with active methylene compounds (dimethyl malonate, malononitrile, 1-methyloxindole, 3-methyl-5-oxo-1-phenyl-2-pyrazoline, 3-ethylrhodanine) to give the displacement products of a methylthio group in good yields. The reaction of IIb, c, d with malonitrile, nitromethane, 1,2,3,4-tetrahydroisoquinoline-1,4-dione, 2,3-dihydrobenzo [b] thiophen-3-one 1,1-dioxide, and 1,3-indadione gave the corresponding heterocyclic compounds, 2-hydroximino-5-oxopyrroline (X), 2-pyridone (VII), pyrrolo [1,2-b] isoquinoline (XIIIa, b), pyrido [2,3-b] benzo [b] thiophene 5,5-dioxide (XVIa, b), and indeno [1,2-b] pyridine (XVIII), derivatives in good yields.
社団法人日本薬学会の論文
1979-12-25