薬剤粉末の混合に関する研究(第3報) : 凝集性粉体のV型混合機内での挙動

概要

論文の詳細を見る
Most of the fine powders used in pharmaceutical preparation are different in their cohesiveness and particle density from particulate solids in other industries, and it is assumed that the behavior of fine powder in the mixer differs from them. Very early stages of the progress of mixing were examined in the V-type mixer, using antipyrin and lactose powder screened into the fraction of -100/+150 mesh, and mixing ratio of 1 : 25. It has been observed that the circulating flows of a mass of particles exist in the V-type mixer and are independent of each shell in the case of such particulate solids as glass bead or Soma sand. This kind of flow was not observed in the present case when the active ingredient was charged to the bottom of mixer. Variation of concentration was traced at some places on the 1st and 2nd layers and results are shown in Fig.6(a)-(e). These peculiar trends auggest that the mixing process was just like 'diffusion' from the charging position of active ingredient. Another charging position (Fig.1) was employed to compare the mixing rate with this position.
社団法人日本薬学会の論文
1970-12-25