薬剤粉末の混合に関する研究(第4報) : ラジオ・アイソトープによる微量混合の検討

概要

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Micro-mixing of potato starch and sodium hydrogencarbonate under a very high dilution ratio (2500-100000) has been studied using the radioactive tracer technique. In the present work, potato starch as a model of potent drug was combined with radioactive iodine ^<125>I (Elementary in ethanol, γe=35 keV, T1/2=60.0 d, 3.0mCi). Under such a dilution ratio, the theoretical sample variance of fully random mixing obtained from Stange's equation (1) can be derived to equation (2') and this suggests that the state of fully random mixing does not depend on the particle size characteristics of diluent. The result of mixing using two size ranges (-150+250,-250 mesh) of diluent followed the tendency expected from eqaution (2') and these were supported by the statistical test. The uniformity of variance of 6 batches of mixing in each dilution ratio was tested and the stability of the state of mixing at the given operation condition was confirmed.
社団法人日本薬学会の論文
1972-03-25