遠心法による薬剤粉末の付着力の測定(第1報)

概要

論文の詳細を見る
Using tablet surface, adhesive forces between the same or different kinds of pharmaceutical powder were measured by the centrifugal method. Materials used were salicylic acid, sodium hydrogencarbonate, potassium hydrogencarbonate, sodium citrate, and polished iron plate. In this measurement, and adhesive force between the same kind of particles was discussed only with salicylic acid and sodium hydrogencarbonate, and for forces between the different kinds of particles or between the particle and the plate, with all four powders and the iron plate. It was found that the contact time before the measurement had a considerable influence on the result. In the case of different kinds of particles, especially when they react with each other, the adhesive forces depend on which kind of particles is tabletted. Namely when the scattered material and tabletted material were exchanged, the results were different after a long contact time (90 min), but it was not so different after a short contact time (20 min). The theories proposed by Iinoya, Rumpf and Newitt were applied to the discussion about the tendency of the results.
社団法人日本薬学会の論文
1969-11-25