含窒素複素環化合物のアンモ酸化に関する研究(第5報)ルチジンの気相アンモ酸化によるジシアノピリジンの合成

概要

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The vapor-phase ammoxidation of 2,5-lutidine was studied in a flow reactor system at atmospheric pressure. This reaction was carried out over several catalysts, V_2O_5-Al_2O_3,V_2O_5-K_2O-Al_2O_3,V_2O_5-pumice stone, V_2O_5-MoO_3-pumice stone, and V_2O_5-Cr_2O_5-pumice stone, The activity and selectivity of these catalysts were compared for the synthesis of dicyanopyridine. The best catalyst among them was 1% Cr_2O_3-10% V_2O_5-pumice stone. Over this catalyst, 2,5-dicyanopyridine was produced with 60% yield at a temperature of 410° and the side reaction to 3-cyanopyridine was negligible. The effect of temperature, contact time, partial pressure of ammonia, and partial pressure of oxygen were also studied. It was found that this reaction is a consecutive reaction in which the methyl group at 2-position is oxidized at first and 2,5-lutidine was converted to 2-cyano-5-methyl-pyridine, which was then oxidized to 2,5-dicyanopyridine.
社団法人日本薬学会の論文
1978-10-25