Studies on the Ammoxidation of N-Heterocyclic Compounds. IV. Vapor-Phase Ammoxidation of Lutidine Isomers

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The kinetics of heterogeneous vapor-phase ammoxidation of lutidine isomers was studied over a Cr_2O_3-Al_2O_3 catalyst in a flow system. The reaction was carried out at atmospheric pressure and at a temperature of 360°. 3-Cyano-5-methylpyridine, 4-cyano-3-methylpyridine, 2-cyano-6-methylpyridine, 2-cyano-5-methylpyridine and 2-cyano-3-methylpyridine were produced selectively at low conversion from 3,5-lutidine, 3,4-lutidine, 2,6-lutidine, 2,5-lutidine and 2,3-lutidine respectively. 2-Cyano-4-methylpyridine and 4-cyano-2-methylpyridine were produced in same amounts from 2,4-lutidine. The reaction rate depended on the partial pressure of lutidine and oxygen. Experimental rate data were well interpreted by Langmuir-Hinshelwood mechanism, where the rate determining step was the surface reaction between adsorbed lutidine molecules and adsorbed oxygen molecules.
社団法人日本薬学会の論文
1974-10-25