アルミナ触媒充填層反応装置によるエチレンジアミンとエチレングリコールの気相反応その2 反応機構の考察

概要

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Several pyrazine derivatives were synthesized by using 1,2-propylenediamine and 1,2-propylene glycol as the starting material. 2,6-Dimethyl-(I), 2,5-dimethyl-(II), 2,5-dimethyl-3-n-propyl-(IV), and 2,6-dimethyl-3-n-propyl-pyrazines (V) were thereby obtained. At a lower temperature of 350° and a molar ratio of propylene glycol to propylene diamine of 3,the main products were IV and V, while at a higher temperature of 400° nearly the same amount of I, II, IV, and V was obtained. It was concluded from these experimental results that both the condensation and deaminocyclization occurred in this method of synthesis, as was suggested earlier. At a temperature below 370°, only the condensation reaction progresses whereas both condensation and deaminocyclization progress at above 370°. When the molar ratio of the starting materials is lower than 0.5,deaminocyclization is predominant.
公益社団法人日本薬学会の論文
1973-03-25