Uracil Derivatives. V. Syntheses and Growth-Inhibitory Activity against L-1210 Cells of 5-Substituted 2'-Deoxyuridines and Orotidine Derivatives
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概要
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5-Benzyloxymethyl-2'-deoxyuridine 3', 5'-di-p-toluate (III), a key intermediate in the preparation of 5-substituted 2'-deoxyuridines (VIa-d), was prepared in satisfactory yield. 5-(4-Substituted phenylthiomethyl)-2'-deoxyuridines (VIa-d) were synthesized in three steps from III. The reaction of silylated orotates (VIIa-e) with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (VIII) gave the N_1,N_3-bisribosides (IXa-e) and the N_3-ribosides (Xa-e). The N_3-ribosides (Xa-e) were deprotected to give the N_3-nucleosides (XIa-e). Compounds VIa-d and XIa-e were tested for ability to inhibit the growth of L-1210 cells in vitro.
- 公益社団法人日本薬学会の論文
- 1985-02-25
著者
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岡田 壽太郎
Faculty of Pharmaceutical Sciences, Kyoto University
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中野 功一
Faculty of Pharmaceutical Sciences, Kyoto University
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三宅 宏
Faculty Of Pharmaceutical Sciences Kyoto University
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岡田 壽太郎
京都大学薬学部
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中野 功一
Faculty Of Pharmaceutical Sciences Kyoto University
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岡田 壽太郎
Faculty Of Pharmaceutical Sciences Kyoto University
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