Effect of Lubricant on Die Wall Friction during the Compaction of Pharmaceutical Powders
スポンサーリンク
概要
- 論文の詳細を見る
The wall friction of pharmaceutical powders (lactose, sucrose, sodium chloride, potassium chloride and sodium bicarbonate) was measured. The sample powders were compressed against a stainless steel wall. Then, keeping the normal pressure (P_N) constant, the wall was slid. During the sliding, the displacement of the wall and the normal and tangential pressures were recorded. For lactose and sucrose powders, the coefficients of wall friction (μ_w) were higher than those for the other powders. The effects of lubricants (magnesium stearate and talc) on μ_w and on the sliding process were examined. The values of μ_w for lubricated powders were 0.22 or less, being slightly dependent on P_N. The residual layer on the wall surface and the replicas of particles on the surface of the compact at various stages during the sliding process were examined. It was found that the junctions between the particles and the die wall grew in size during the course of sliding, and that the lubricants prevented this growth, resulting in decreases of the friction and adhesion forces.
- 公益社団法人日本薬学会の論文
- 1982-02-25
著者
-
岡田 寿太郎
京都大学 薬
-
岡田 寿太郎
Faculty of Pharmaceutical Sciences, Kyoto University
-
岡田 壽太郎
京都大学薬学部
-
平井 淑子
Faculty of Pharmaceutical Sciences, Kyoto University
-
岡田 寿太郎
Faculty Of Pharmaceutical Sciences Kyoto University
-
平井 淑子
Faculty Of Pharmaceutical Sciences Kyoto University:(present Address)faculty Of Phamacy Meijo Univer
関連論文
- 薬学図書館をかんがえる
- 塩化カリウム錠剤杵接触面における垂直圧力分布の測定
- Analysis of the Stress and Strain Distributions in the Compressed Powder in the Limiting Equilibrium States Specified by the Mohr Criterion. Theory and Measurements of Mechanical Properties
- Compaction of Powders. III. Comparison of Compaction Behaviours among Various Powders
- 粉体の圧縮成形に関する研究(第2報)塩化カリウム粉体の臼圧縮における下杵への圧力伝達
- Compaction of Powders. I. Compression under the Constant Upper Punch Pressure and Behavior of Particle Filling in Void
- Syntheses and Analgesic Activities of 1-[2-Methyl-2-(N-propionyl-p-or m-substituted-phenylamino) ethyl]-4-phenethylpiperazines
- Stability of Packaged Solid Dosage Forms. V. Prediction of the Effect of Aging on the Disintegration of Packaged Tablets influenced by Moisture and Heat
- Kinetic Studies on an Improved Williamson Ether Synthesis Using a Polymer-Supported Phase-Transfer Catalyst
- 三相系触媒反応の研究 : 固定化された4級塩の構造が触媒活性に及ぼす影響
- 樹脂固定化相間移動触媒 : ブロミドイオン置換反応の速度論及び総括反応速度に及ぼす物質移動の影響
- Polymer-Supported Phase Transfer Catalysis : Kinetics of a Bromide Ion Displacement Reaction and the Effect of Mass Transfer on the Global Rate of Reaction
- Liquid-phase Oxidation of Ethylene Glycol on a Pt/C Catalyst. II. Kinetic Studies
- Liquid-Phase Oxidation of Ethylene Glycol on a Pt/C Catalyst. I. Deactivation and Regeneration of the Catalyst
- Liquid-Phase Oxidation of Diethanolamine on a Pd-Al_2O_3 Catalyst. II. The Effect of Mass Transfer on the Global Rate of Reaction
- Liquid-Phase Oxidation of Diethanolamine on a Pd-Al_2O_3 Catalyst. I. Kinetic Studies
- Kinetic Studies on the Catalytic Synthesis of Benzyl Cyanide from 2-Phenylethanol and Ammonia
- トリメチレンジアミンとウレタンの気相反応
- 含窒素複素環化合物のアンモ酸化に関する研究(第6報)ピコリン類およびメチルジアジン類の気相アンモ酸化
- 含窒素複素環化合物のアンモ酸化に関する研究(第5報)ルチジンの気相アンモ酸化によるジシアノピリジンの合成
- Vapor-Phase Ammoxidation of 5-Membered Heterocyclic Compounds. Ammoxidation of Furfural and 2-Thiophenealdehyde
- Studies on the Ammoxidation of N-Heterocyclic Compounds. IV. Vapor-Phase Ammoxidation of Lutidine Isomers
- 含窒素異項環化合物のアンモ酸化に関する研究(第3報)4-ピコリンおよび2-ピコリンの気相アンモ酸化
- 含窒素異項環化合物のアンモ酸化に関する研究(第2報)Cr_2O_3-Al_2O_3触媒による3-ビコリンの気相アンモ酸化に関する速度論的研究
- フルフラールの液相アンモ酸化に関する速度論的研究
- 気液向流型多段反応装置によるフルフラールの液相アンモ酸化
- 気液向流型多段反応装置の研究(第3報) : ベンズアルデヒドの液相アンモ酸化
- ベンズアルデヒドの液相アンモ酸化に関する動力学的研究
- Liquid-Solid Mass Transfer in Packed-Bed Reactors with Porous Particles
- 臨床試験における欠測値の取り扱いに関する考察
- 脱水環化脱水素による2-アルキルピリミジン類の合成
- 白金族金属-アルミナ触媒によるトリメチレンジアミンから2-エチルピリミジンの生成とその動力学
- Uracil Derivatives. V. Syntheses and Growth-Inhibitory Activity against L-1210 Cells of 5-Substituted 2'-Deoxyuridines and Orotidine Derivatives
- 1,2-Cyclohexanedioneの光化学反応生成物の構造(第3報)
- Oxidation of Glucose on Immobilized Glucose Oxidase : Trickle-Bed Reactor Performance
- Kinetic Studies on the Oxidation of Glucose by Immobilized Glucose Oxidase
- Uracil Derivatives. IV. Growth-Inhibitory Activity against L-1210 Cells of Orotic Acid Derivatives and Synthesis of 1-(β-D-Ribofuranosyl) furo [3,4-d] pyrimidine-2,4,7 (1H, 3H, 5H)-trione
- 薬学生の独語教育(薬学教育における第2外国語教育)
- Application of a Membrane Reactor to Gas-Liquid Two-phase Enzyme : Reactions : Oxidation of Glucose by Soluble Immobilized Glucose Oxidase and Catalase
- Calculated Stress and Strain Conditions of Lubricated Potassium Chloride Powders during Die-Compression
- Oxidation of Glucose on Immobilized Glucose Oxidase in a Trickle-Bed Reactor : Effect of Liquid-Solid Contacting Efficiency on the Global Rate of Reaction
- Effect of Lubricant on Die Wall Friction during the Compaction of Pharmaceutical Powders
- Uracil Derivatives. III. Syntheses and Growth-inhibitory Activity against L-1210 Cells of 5,6-Disubstituted Uracils
- Uracil Derivatives. II. Syntheses and Growth-inhibitory Activity against L-1210 Cells of 5-(4-Substituted-phenylthiomethyl)-6-carbamoyluracils
- 充填層反応装置によるトリメチレンジアミンとエチレングリコールの気相反応
- Syntheses of N-(1-Methyl-2-piperazinoethyl) propionanilides and 2-Alkoxy-6-[N-[1-methyl-2-(4-phenethylpiperazino) ethyl]-propionamide] benzothiazoles
- Syntheses of N-(2-Hexahydropyrimidinoethyl) propionanilides
- Liquid-Solid Contacting Efficiency in Trickle-Bed Reactors
- 薬剤粉体の圧縮成形における滑沢剤の影響--塩化カリウム主薬の機械的性質の変化 (粉体層ノ静力学的特性--測定法とモデル論)
- N-(2-Piperazinoethyl)propionanilide類の合成
- 粉体の圧縮成型における滑沢剤の影響, 圧縮過程の変化
- Mixing of Pharmaceutical Powders examined by Use of Colored Particles : Discussions on Coloration Difference
- Flocculation Studies of Granulated Stearyl Alcohol on the Surface of Aqueous Media. III. : Changes of Agglomerate Structure in a Two-Dimensional System with Anionic Surface-Acitive Agent
- アルミナ充填層反応装置によるジアミンとグリコールの反応 : KOH 添加による触媒酸性度, 細孔構造の変化に関して
- Syntheses and Antitumor Activities of 5-(Substituted-methyl)-6-carbamoyluracils
- The Structure of 1,2-Cyclohexanedione Photoproduct. II
- 1,2-Cyclohexanedioneの光化学反応生成物の構造(第1報)
- 脂環式ケトンの光化学反応
- アルミナ触媒充填層反応装置におけるホルムアルデヒドとエチレンジアミンの反応
- アルミナ充填層反応装置によるトリメチレンジアミンとホルマリンの気相反応
- 粉体の研究から
- アルミナ充填層反応装置によるトリメチレンジアミンとプロピレングリコールの反応 : 実験計画法によるホモピペラジン収率最適条件の探索
- 1,3-DiazineのN-アセチル化
- 2-(1-Cyclohexenyl)cyclohexanoneを原料とする合成研究
- Comparison of Lubricant Efficiencies during Compaction of Lactose Powder
- アルミナ充填層反応装置によるエチレンジアミンとプロピレングリコールの反応 : 実験計画法によるメチルピペラジン収率, 最適条件の探索
- Flocculation Studies of Granulated Stearyl Alcohol on the Surface of Aqueous Media. II. : Flocculation-Deflocculation Mechanism in a Two-Dimensional System
- トリメチレンジアミンとアルデヒド類の環化脱水素による2-アルキルピリミジン類の合成とその動力学
- ^C Nuclear Magnetic Resonance Spectra of Antipyrine Derivatives and Their Application to Hansch Analysis
- バルビツール酸誘導体のC-13 NMRスペクトル(第3報)
- C-13 NMR Spectra of Barbituric Acid Derivatives. II