^<13>C Nuclear Magnetic Resonance Spectra of Antipyrine Derivatives and Their Application to Hansch Analysis

概要

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The ^<13>C nuclear magnetic resonance spectra of thirty 4-substituted antipyrine derivatives were examined to obtain the following conclusions : (i) the shielding constants of antipyrine were estimated using the CNDO/2 method ; the signal assignment using the shielding constants was consistent with that based on the experiments ; (ii) the ^<13>C-^2H coupling constants of antipyrine were estimated using the CNDO/2 method ; the calculated values are in good agreement with those observed ; (iii) the additive equation on the chemical shifts of the sp^3-hybridized carbon was estimated ; the so-called steric effects were observed as a result of this analysis ; and (iv) the Hansch analyses were carried out regarding C-4 of the antipyrine derivatives as the so-called biological active center ; the agreement between the values estimated by the Hansch equation and those observed was fairly good for the analgesic activities.
公益社団法人日本薬学会の論文
1976-01-25