粉体の圧縮成型における滑沢剤の影響, 圧縮過程の変化

概要

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During a direct-compression, the effect of magnesium stearate as a lubricant was examined. Potassium chloride, lactose, sodium bicarbonate powder, and their lubricated powder were filled and compressed by the upper punch, measuring the upper punch pressure, lower punch pressure, and thickness of the powder bed. In the case of lubricated powders, three patterns for the three unlubricated powders in changes of pressuretransmission ratio with the increase of upper punch pressure changed to the type of monotonous increase, and the pressure-transmission ratio increased. remarkedly. On the other hand, the lubricated powders showed a lower porosity than the unlubricated powders, but they remained in the same patterns of the porosity-upper punch pressure curve for each of unlubricated powders. Photomicrographs of the replicated surface of lubricated and unlubricated tablets were compared. The lubricated tablets showed equalization of density by distribution.
公益社団法人日本薬学会の論文
1978-10-25