テトラフルオロエチレンプラズマ重合膜による固形薬剤の徐放化の試み

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Some solid drugs containing water-soluble pharmaceuticals were coated by thin film of plasma-polymerized tetrafluoroethylene produced in a glow discharge of the monomer gas under reduced pressure and the possibility of slow release of the pharmaceuticals as a result of the plasma coating was investigated. Lysozyme chloride and nicotinic acid were chosen as model pharmaceuticals having large and small molecular sizes and the rates of dissolution from tablets, powders, and granules in aqueous medium were measured by light absorption of the aqueous solutions of the pharmaceuticals. It has been observed that the slow release of the pharmaceuticals from the solid drugs was fairly well controlled by changing film thickness of the plasma-polymer, while, in the case of powder drug, mixing of the material during the plasma process was essential to ensure homogeneous exposure of the entire powder material to the plasma gas. It has been also supposed that the lysozyme chloride having large molecular size was not permeable through the coating film but it was released through cracks produced by expan sion of the drugs after absorption of moisture through the coating film and/or imperfect spots of the coating film possibly located at deep cavities on the surfaces of the solid drugs, while the nicotinic acid having relatively small molecular size was released not only through the cracks and imperfect spots but also through the coating film by permeation.
公益社団法人日本薬学会の論文
1983-07-25

テトラフルオロエチレンプラズマ重合膜による固形薬剤の徐放化の試み

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