Control of Antipyrine Release Rate by Plasma Coating Using Tetrafluoroethylene and Propargyl Alcohol Blend Monomer(Physical,Chemical)

概要

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Antipyrine powder was coated by deposition of a polymer thin film within a glow discharge of tetrafluoroethylene and propargyl alcohol blend monomer under reduced pressure (plasma polymerization) and drug release from the product was investigated. A dissolution test revealed that the use of the blend monomer was superior to that of the individual plain monomer. The plasma coating of the powder was done with intermittent agitation or with continuous mixing under electromechanical vibration; in the former case the product gave slow drug release, but the reproducibility was poor, while in the latter case, reproducibility was good, but the release rate was faster. It was found that the release rate could be fairly well controlled by changing the film thickness of the plasma polymer, and was not influenced by the pH of the dissolution medium.
社団法人日本薬学会の論文
1987-11-25