エキヌリンおよび関連化合物の合成研究(第4報) : Aspergillus amstelodamiから得られるフラボグラウシン, オーログラウシン型天然物の抽出, 構造および合成

概要

論文の詳細を見る
Five natural products, named E-1,E-2,E-3,E-4,and E-5,were isolated from hexane extract of freeze-dried mycelium of Aspergillus amstelodami IFO-6667. E-4 and E-5 were found to be identical with flavoglaucin (1) and auroglaucin (2), respectively, from spectroscopic and melting point data. The structure of E-3 was elucidated as 3 mainly from analysis of spectroscopic data. The structure 3 had already been given to aspergin, but the melting point of E-3 did not agree with the reported melting point of aspergin. The structure of E-3 was confirmed by its total synthesis. The structure of E-1 and E-2 was determined as 8 and 13 by analysis of spectroscopic data. The structure 8 was confirmed by its total synthesis. One-step transformation of auroglaucin (2) into E-2 was achieved by heating 2 in dimethyl sulfoxide containing Triton-B.
社団法人日本薬学会の論文
1977-05-25