海ホタルLuciferinおよび関連物質の合成研究(第10報) : ImidazopyridineおよびImidazopyrazineの各種誘導体の化学発光能

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Chemiluminescences of cypridina luciferin in aprotic solvents and the structure necessary for the production of light is 3,7-dihydroimidazo[1,2-α]pyrazin-3-one. Chemiluminescence ability of 2-hydroxy-, 3-amino- and 3-hydroxy-imidazo[1,2-α]pyridine derivatives, 3,7-dihydroimidazo[1,2-α]pyrazin-3-one derivatives, and 3-aminoimidazo[1,2-α]pyrazine derivatives was tested in diglyme and in dimethyl sulfoxide solutions. Chemiluminescence of dihydroimidazopyrazinones is very much stronger than that of 3-hydroxyimidazopyridines and the amino derivatives produce almost no light. In the case of 6-(3-indolyl)-imidazopyrazinone derivatives the light yield is extremely enhanced by the addition of a trace of acetate buffer in the reaction mixture (Table II) ; the chemiluminescence light yiled of Cypridina luciferin(I), which has a 3-indolyl group at 6-position, is 0.06 which is ca. 15% of its bioluminescence light yield.
公益社団法人日本薬学会の論文
1970-12-25