複素環化合物の開環反応の研究(第5報) : N-(2,4-Dinitrophenyl)-pyridinium Chlorideと活性メチレン化合物との反応

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概要

• 論文の詳細を見る

• Reactions of N-(2,4-dinitrophenyl) pyridinium chloride (I) with five active methylene compounds were found to proceed by the following three routes. Malonodinitrile and ethyl cyanoacetate attacked the α-position of the pyridine ring in I, resulting in the rupture of a C-N bond, and thus gave 1-(2,4-dinitroanilino)-6,6-dicyano-1,3,5-hexatriene (II) and 1-(2,4-dinitroanilino)-6-ethoxycarbonyl-6-cyano-1,3,5-hexatriene (III). Diethyl malonate and malonodiamide added at γ-position of the pyridine ring to give N-(2,4-dinitrophenyl)-4-diethoxycarbonylmethyl-1,4-dihydropyridine (V) and N-(2,4-dinitrophenyl)-4-dicarbamoylmethyl-1,4-dihydropyridine (VI). Cyanoacetamide added at α-position of the pyridine ring to give N-(2,4-dinitrophenyl)-2-(α-carbamoyl) cyanomethyl-1,2-dihydropyridine (VII).

• 公益社団法人日本薬学会の論文
• 1972-04-25

著者

• 田村 恭光

  Faculty Of Pharmaceutical Sciences Osaka University

• 田村 恭光

  大阪大学薬学部

• 真野 光彦

  大阪大学薬学部

• 須本 国弘

  大阪大学薬学部

• 増井 武彦

  大阪大学薬学部

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