Studies on Ring-opening of Heterocyclic Compounds. III. Alternative Preparation of Isoquinoline N-Oxide and N-Imine
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概要
- 論文の詳細を見る
Isoquinoline N-oxide (5) and N-imine (8) were prepared by ring-opening reactions of quarternary isoquinolinium salts and successive ring-closures. The ring-opening reaction of N-(2,4-dinitrophenyl) isoquinolinium chloride (1) with hydroxylamine gave o-[2-(2,4-dinitroanilino) vinyl] benzaldehyde oxime (2), which cyclized by refluxing in concentrated hydrochloric acid-ethanol (3 : 40) to isoquinoline N-oxide (5) in 53% yield from isoquinoline. This method was applied to the preparation of isoquinoline N-imine (8). An equimolar mixture of N-(2,4-dinitrophenyl) isoquinolinium chloride (1) and hydrazine hydrate in dioxane-water (4 : 1) was heated under reflux to give isoquinoline N-imine (8) in 50% yield from isoquinoline.
- 公益社団法人日本薬学会の論文
- 1971-01-25
著者
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田村 恭光
Faculty Of Pharmaceutical Sciences Osaka University
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辻本 信子
大阪大学薬学部
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辻本 信子
Faculty of Pharmaceutical Sciences, Osaka University Toneyama, Toyonaka, Osaka
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内村 美智子
Faculty of Pharmaceutical Sciences, Osaka University
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内村 美智子
Faculty Of Pharmaceutical Sciences Osaka University
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