Synthesis and Application of Imidazole Derivatives. Synthesis of 5-Methyl-7,8,9,10-tetrahydro-5H-azepino[1,2-α]benzimidazol-7-one and Related Compounds

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概要

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• 5-Methyl-7,8,9,10-tetrahydro-5H-azepino[1,2-α]benzimidazol-7-one (6) was synthesized by treating 1-(3-carboxypropyl)-2,3-dimethylbenzimidazolium iodide (11) with 1,1'-carbonyldiimidazole in the presence of triethylamine. Refluxing 2-(5-chloro-2-oxopentyl)-1-methylbenzimidazole (4) in ethyl acetate did not afford 6 but gave (Z)-1-methyl-2-(2,3,4,5-tetrahydro-2-furylidenemethyl)benzimidazole (5), which was rearranged to the corresponding (E)-isomer (7) by heating in ethyl acetate in the presence of basic alumina. The structures of 5,6 and 7 were determined by X-ray crystallography.

• 公益社団法人日本薬学会の論文
• 1990-02-25

著者

• 太田 俊作

  Kyoto Pharmaceutical University

• 岡本 正夫

  Kyoto Pharmaceutical University

• 太田 俊作

  京都薬科大学薬学部

• 成田 善弘

  Kyoto Pharmaceutical University

• 畠山 祥子

  Kyoto Pharmaceutical University

• 管 慶三

  Kyoto Pharmaceutical University

• 湯浅 輝之

  Kyoto Pharmaceutical University

• 早川 久美子

  Kyoto Pharmaceutical University

• 太田 俊作

  Kyoto College Of Pharmacy

• 管 慶三

  Faculty Of Pharmaceutical Sciences Okayama University

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