Synthesis and Application of Imidazole Derivatives. Introduction of Carbogenic Substituents into the 5-Position of 1-Methyl-1H-imidazole

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概要

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• The 5-position of 1-methyl-2-phenylthio-1H-imidazole (12a) was lithiated by lithium 2,2,6,6-tetramethylpiperidide, and the produced carbanion was reacted with various electrophiles to give the corresponding 5-substituted derivatives in good yields. The reaction position was confirmed by ^1H-NMR spectroscopy and X-ray crystallography. The phenylthio group of the 5-substituted compounds could be easily removed by treatment with Raney-nickel.

• 社団法人日本薬学会の論文
• 1992-10-25

著者

• 山本 徹也

  Kyoto Pharmaceutical University

• 太田 俊作

  Kyoto Pharmaceutical University

• 山下 正行

  Kyoto Pharmaceutical University

• 川崎 郁勇

  Kyoto Pharmaceutical University

• 小川 和男

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 奥山 和典

  Kyoto Pharmaceutical University

• 勝間 英雄

  Kyoto Pharmaceutical University

• 名迫 理恵子

  Kyoto Pharmaceutical University

• 小林 和弘

  Medicinal Research Center of Taiho Pharmaceutical Co., Ltd.,

• 小川 和男

  Medicinal Research Center of Taiho Pharmaceutical Co., Ltd.,

• 川崎 郁勇

  京都薬大

• 太田 俊作

  京都薬科大学薬学部

• 小林 和弘

  Medicinal Research Center Of Taiho Pharmaceutical Co. Ltd.

• 太田 俊作

  Kyoto College Of Pharmacy

• 山下 正行

  京都薬科大学薬学部

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