An Improved Procedure for the Synthesis of 1-Alkyl-5-(alkylamino)-imidazole-4-carboxamides, Synthetic Intermediates for 3,9-Dialkylpurine Derivatives

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概要

• 論文の詳細を見る

• Heating N, N-diethyl-3,9-dialkyladeninium halides (Ig-j) in aqueous sodium hydroxide gave 1-alkyl-5-(alkylamino)imidazole-4-carboxamides (IV) together with minor amounts of 1-alkyl-5-(alkylamino)imidazole-4-carbonitriles (III), which were converted into IV on further heating. N, N-Dimethyl-3,9-dialkyladeninium halides (Ia-d) underwent hydrolysis more rapidly to provide IV selectively in 90-94% yields.

• 公益社団法人日本薬学会の論文
• 1980-09-25

著者

• 小川 和男

  Tokushima Research Center, Pharmacokinetics Research Lab., Taiho Pharmaceutical Co., Ltd.,

• 小川 和男

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 板谷 泰助

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 渡辺 朝子

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 板谷 泰助

  金沢大学薬学部

• 松本 浩郎

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 松本 浩郎

  Central Research Institute, Nissan Chemical Ind. Ltd.

• 松本 浩郎

  Central Research Institute Nissan Chemical Ind. Ltd.

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