Synthesis and Biological Activities of 1-[2-(Dimethylamino)ethyl]- and 1-[3-(Dimethylamino)propyl]-substituted 3-Methyl-1,8-dihydrocycloheptapyrazol-8-ones and Related Compounds
スポンサーリンク
概要
- 論文の詳細を見る
3-Methyl-1,8-dihydrocycloheptapyrazol-8-ones (2a-c), prepared from 3-acetyltropolones (1a-c), were treated with diazomethane, methyl iodide, dimethyl sulfate, and diethyl sulfate to give 1- and 2-alkylated compounds. The 1,8-dihydrocycloheptapyrazol-8-one (2a) also reacted with 2-(dimethylamino)ethyl, 2-(diethylamino)ethyl, 3-(dimethylamino)propyl, and 2,3-dihydroxypropyl chloride to afford the corresponding 1-substituted products. A preliminary study was made of the biological activities of some of the obtained compounds.
- 社団法人日本薬学会の論文
- 1992-06-25
著者
-
小川 和男
Tokushima Research Center, Pharmacokinetics Research Lab., Taiho Pharmaceutical Co., Ltd.,
-
小川 和男
Research Institute, Taiho Pharmaceutical Co., Ltd.
-
小川 和男
Faculty Of Pharmaceutical Sciences Kanazawa University
-
今福 公明
Department of Chemistry, Faculty of Science, Kumamoto University
-
荒殿(旧姓新井) 清美
Department of Chemistry, Faculty of Science, Kumamoto University
-
魚野 マガリー
Department of Chemistry, Faculty of Science, Kumamoto University
-
松下 洋一
Research Institute, Taiho Pharmaceutical Co., Ltd.,
-
松下 洋一
Research Institute Taiho Pharmaceutical Co. Ltd. :(present Address)department Of Industrial Chemistr
-
今福 公明
Department Of Chemistry Faculty Of Science Kumamoto University
-
魚野 マガリー
Department Of Chemistry Faculty Of Science Kumamoto University
-
荒殿(旧姓新井) 清美
Department Of Chemistry Faculty Of Science Kumamoto University
関連論文
- Piperazinealkanol Ester Derivatives of Indomethacin as Dual Inhibitors of 5-Lipoxygenase and Cyclooxygenase
- Syntheses and Chemical Properties of Novel 1,3-Oxathiolan-5-one Derivatives
- Ring Opening of Cyclopropanemonocarboxylates and 1,1-Cyclopropanedicarboxylates Using Samarium(II) Diiodide (SmI_2)-HMPA-THF System
- Purines. LXX. An Extension of the "Phenacylamine Route" to the Syntheses of the 7-N-Oxides of 6-Mercaptopurine and 6-Methylthiopurine, and Antileukemic Activity of Some Purine N-Oxides
- Purines. LXIX. Direct N(1)-Oxidation of 7-Benzyladenine and Stepwise Syntheses of Its N(1)- and N(3)-Oxides
- Purines. LXVIII. Trifluoroperoxyacetic Acid Oxidation of N^6-Benzyladenine : Formation of the N(3)-Oxide and N(7)-Oxide, and Their Cytokinin Activities
- Purines. LXVII. An Alternative Synthesis of Adenine 7-Oxide : N-Oxidation of the Adenine Ring Utilizing Blocking/Deblocking at the 1-Position
- Purines. LXVI. Adenine 7-Oxide : Its Synthesis, Chemical Properties, and X-ray Molecular Structure
- Synthesis and Application of Imidazole Derivatives. Introduction of Carbogenic Substituents into the 5-Position of 1-Methyl-1H-imidazole
- Synthesis and Antiarrhythmic Activity of 2,5-Disubstituted 2,3-Dihydro-1,2,5-benzothiadiazepin-4(5H)-one 1,1-Dioxides
- Synthesis and Biological Activities of 1-[2-(Dimethylamino)ethyl]- and 1-[3-(Dimethylamino)propyl]-substituted 3-Methyl-1,8-dihydrocycloheptapyrazol-8-ones and Related Compounds
- Purines. LII. Synthesis and Biological Evaluation of 8-Methylguanine 7-Oxide and Its 9-Arylmethyl Derivatives
- Purines. LI. Synthesis and Biological Activity of Hypoxanthine 7-N-Oxide and Related Compounds
- Purines. L. Synthesis and Antileukemic Activity of the Antibiotic Guanine 7-Oxide and Its 9-Substituted Derivatives
- Synthesis and Antiestrogenic Activity of the Compounds Related to the Metabolites of (Z)-4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-(4-isopropylphenyl)-1-butenyl]phenyl Monophosphate (TAT-59)
- Synthesis and Biological Activity of the Metabolites of [3,4-Bis(4-methoxyphenyl)-5-isoxazolyl]acetic Acid
- Studies on Hypolipidemic Agents. V. Synthesis and Esterase-Inhibitory Activity of 2-(1,4- and 4,4-Dialkylcyclohexyl)-2-oxoethyl Arenesulfonates(Medicinal Chemistry,Chemical)
- Studies on Hypolipidemic Agents. III. Synthesis and Esterase-Inhibitory Activity of ω-Cycloalkyl-2-oxoalkyl Arenesulfonates(Medicinal Chemistry,Chemical)
- Studies on Hypolipidemic Agents. II. : Synthesis of 1-Arenesulfonyloxy-2-alkanone Derivatives as Potent Esterase Inhibitors and Hypolipidemic Agents
- Studies of Hypolipidemic Agents. I. : Syntheses and Hypolipidemic Activities of 1-Substituted 2-Alkanone Derivatives
- An Improved Procedure for the Synthesis of 1-Alkyl-5-(alkylamino)-imidazole-4-carboxamides, Synthetic Intermediates for 3,9-Dialkylpurine Derivatives
- Synthesis of N, N, 3,9-Tetraalkyladeninium Halides by Alkylations of N, N, 3- and N, N, 9-Trialkyladenines
- 3,9-Dialkylhypoxanthines
- Syntheses of Pyrazolo [1,2-a] pyrazole and Pyrazolo [5,1-b] [1,3] oxazine Derivatives
- Syntheses of N, N, 3- and N, N, 9-Trialkyladenines by Alkylation of N, N-Dialkyladenines