Syntheses and Chemical Properties of Novel 1,3-Oxathiolan-5-one Derivatives
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概要
- 論文の詳細を見る
2-Aklylidene-4-arylidene-1,3-oxathiolan-5-one (III-1a-m) and 2,4-diarylidene-1,3-oxathiolan-5-one (III-2a-i) derivatives were synthesized by treating β-aryl-α-mercaptoacrylic acids (I) with alkanoic acid anhydrides (II) or by treating α-acylthio-β-arylacrylic acids (V) with thionyl chloride in dimethylformamide. Basic hydrolysis and methanolysis of III-1 and III-2 in the presence of lithium hydroxide easily occurred to give the corresponding ring-cleaved products, the carboxylic acid (I and II) and the ester (VII and VIII), respectively. The catalytic hydrogenation of the two olefinic bonds of III-2 in the presence of 10% palladium charcoal proceeded easily without ring cleavage to give 1,3-oxathiolan-5-one (IXa-e) derivatives. The oxidation of III-1 and III-2 with m-chloroperbenzoic acid afforded the corresponding 1,3-oxathiolan-5-one S-oxide (Xa, b) derivatives.
- 社団法人日本薬学会の論文
- 1985-06-25
著者
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寺田 忠史
Hanno Research Center, Taiho Pharmaceutical Co., Ltd.,
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小川 和男
Tokushima Research Center, Pharmacokinetics Research Lab., Taiho Pharmaceutical Co., Ltd.,
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寺田 忠史
Hanno Research Center Taiho Pharmaceutical Co. Ltd.
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山崎 富生
Research Institute Taiho Pharmaceutical Co. Ltd.
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小川 和男
Research Institute, Taiho Pharmaceutical Co., Ltd.
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山田 省三
Research Institute, Taiho Pharmaceutical Co., Ltd.
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寺田 忠史
Research Institute, Taiho Pharmaceutical Co., Ltd.
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本邦 隆次
Research Institute, Taiho Pharmaceutical Co., Ltd.
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小川 和男
Faculty Of Pharmaceutical Sciences Kanazawa University
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山田 省三
Research Institute Taiho Pharmaceutical Co. Ltd.
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本邦 隆次
Research Institute Taiho Pharmaceutical Co. Ltd.
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