Synthesis and Antiestrogenic Activity of the Compounds Related to the Metabolites of (Z)-4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-(4-isopropylphenyl)-1-butenyl]phenyl Monophosphate (TAT-59)
スポンサーリンク
概要
- 論文の詳細を見る
The metabolites of (Z)-4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-(4-isopropylphenyl)-1-butenyl]phenyl monophosphate, TAT-59,(1), a potent antitumor agent for hormone-dependent tumors, and derivatives of TAT-59 were synthesized to confirm its proposed structure. The structure and the Z-configuration of the metabolites (2a-8a) were confirmed by comparison with synthesized authentic compounds. All of the metabolities and the derivatives of TAT-59 were tested for a binding affinity toward estrogenic receptors in vitro and antiuterotrophic activity in vivo. Most of the metabolites possessed remarkable binding affinity toward estrogenic receptors as well as fairly good antiuterotrophic activity.
- 社団法人日本薬学会の論文
- 1991-04-25
著者
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小川 和男
Tokushima Research Center, Pharmacokinetics Research Lab., Taiho Pharmaceutical Co., Ltd.,
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山脇 一郎
Research Laboratory, Taiho Pharmaceutical Co., Ltd.
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柴田 治郎
Research Laboratory Taiho Pharmaceutical Co. Ltd.
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小川 和男
Research Institute, Taiho Pharmaceutical Co., Ltd.
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小川 和男
Faculty Of Pharmaceutical Sciences Kanazawa University
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浅尾 哲次
Research Laboratory Taiho Pharmaceutical Co. Ltd.
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松下 洋一
Research Institute, Taiho Pharmaceutical Co., Ltd.,
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鐘田 学
Research Laboratory, Taiho Pharmaceutical Co., Ltd.,
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東岡 俊之
Research Laboratory, Taiho Pharmaceutical Co., Ltd.,
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松下 洋一
Research Institute Taiho Pharmaceutical Co. Ltd. :(present Address)department Of Industrial Chemistr
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鐘田 学
Research Laboratory Taiho Pharmaceutical Co. Ltd.
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東岡 俊之
Research Laboratory Taiho Pharmaceutical Co. Ltd.
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山脇 一郎
Tokushima Research Center Pharmacokinetics Research Lab. Taiho Pharmaceutical Co. Ltd.
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