Synthesis and Biological Activity of the Metabolites of syn-3-Ethyl-7-methyl-3,7-diazabicyclo[3.3.1]non-9-yl 4-Chlorobenzoate Hydrochloride

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概要

• 論文の詳細を見る

• Five metabolites of syn-3-ethyl-7-methyl-3,7-diazabicyclo[3.3.1]non-9-yl 4-chlorobenzoate hydrochloride (YUTAC)(1) were prepared and examined for Na^+ current blocking activity in guinea pig ventricular myocytes. These metabolites showed lower inhibitory activities than the parent compound or were inactive.

• 公益社団法人日本薬学会の論文
• 1994-11-15

著者

• 山脇 一郎

  Tokushima Research Center, Pharmacokinetics Research Lab., Taiho Pharmaceutical Co., Ltd.,

• 角南 明彦

  Pharmacology Research Lab. Taiho Pharmaceutical Co. Ltd.

• BUKOVAC Scott

  Tokushima Research Center, Pharmacokinetics Research Lab. Taiho Pharmaceutical Co., Ltd.,

• Bukovac Scott

  Tokushima Research Center Pharmacokinetics Research Lab. Taiho Pharmaceutical Co. Ltd.

• 山脇 一郎

  Tokushima Research Center Pharmacokinetics Research Lab. Taiho Pharmaceutical Co. Ltd.

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• Synthesis and Biological Activity of the Metabolites of syn-3-Ethyl-7-methyl-3,7-diazabicyclo[3.3.1]non-9-yl 4-Chlorobenzoate Hydrochloride

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